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Can incorporating genotyping data into efficacy estimators improve efficiency of early phase malaria vaccine trials?
BACKGROUND: Early phase malaria vaccine field trials typically measure malaria infection by PCR or thick blood smear microscopy performed on serially sampled blood. Vaccine efficacy (VE) is the proportion reduction in an endpoint due to vaccination and is often calculated as [Formula: see text] – ha...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Journal Experts
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543529/ https://www.ncbi.nlm.nih.gov/pubmed/37790581 http://dx.doi.org/10.21203/rs.3.rs-3370731/v1 |