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Influence of variant-specific mutations, temperature and pH on conformations of a large set of SARS-CoV-2 spike trimer vaccine antigen candidates

SARS-CoV-2 subunit vaccines continue to be the focus of intense clinical development worldwide. Protein antigens in these vaccines most commonly consist of the spike ectodomain fused to a heterologous trimerization sequence, designed to mimic the compact, prefusion conformation of the spike on the v...

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Detalles Bibliográficos
Autores principales:	Stuible, Matthew, Schrag, Joseph D., Sheff, Joey, Zoubchenok, Daria, Lord-Dufour, Simon, Cass, Brian, L’Abbé, Denis, Pelletier, Alex, Rossotti, Martin A., Tanha, Jamshid, Gervais, Christian, Maurice, Roger, El Bakkouri, Majida, Acchione, Mauro, Durocher, Yves
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543594/ https://www.ncbi.nlm.nih.gov/pubmed/37779126 http://dx.doi.org/10.1038/s41598-023-43661-2

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