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Positive and negative regulation of the Fcγ receptor–stimulating activity of RNA-containing immune complexes by RNase

The U1RNP complex, Ro/SSA, and La/SSB are major RNA-containing autoantigens. Immune complexes (ICs) composed of RNA-containing autoantigens and autoantibodies are suspected to be involved in the pathogenesis of some systemic autoimmune diseases. Therefore, RNase treatment, which degrades RNA in ICs,...

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Detalles Bibliográficos
Autores principales:	Naito, Ryota, Ohmura, Koichiro, Higuchi, Shuhei, Nakai, Wataru, Kohyama, Masako, Mimori, Tsuneyo, Morinobu, Akio, Arase, Hisashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543717/ https://www.ncbi.nlm.nih.gov/pubmed/37432743 http://dx.doi.org/10.1172/jci.insight.167799

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