Ancestry-based differences in the immune phenotype are associated with lupus activity

Systemic lupus erythematosus (SLE) affects 1 in 537 Black women, which is >2-fold more than White women. Black patients develop the disease at a younger age, have more severe symptoms, and have a greater chance of early mortality. We used a multiomics approach to uncover ancestry-associated immun...

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Detalles Bibliográficos
Autores principales: Slight-Webb, Samantha, Thomas, Kevin, Smith, Miles, Wagner, Catriona A., Macwana, Susan, Bylinska, Aleksandra, Donato, Michele, Dvorak, Mai, Chang, Sarah E., Kuo, Alex, Cheung, Peggie, Kalesinskas, Laurynas, Ganesan, Ananthakrishnan, Dermadi, Denis, Guthridge, Carla J., DeJager, Wade, Wright, Christian, Foecke, Mariko H., Merrill, Joan T., Chakravarty, Eliza, Arriens, Cristina, Maecker, Holden T., Khatri, Purvesh, Utz, Paul J., James, Judith A., Guthridge, Joel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543734/
https://www.ncbi.nlm.nih.gov/pubmed/37606045
http://dx.doi.org/10.1172/jci.insight.169584

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