Pansclerotic morphea is characterized by IFN-γ responses priming dendritic cell fibroblast crosstalk to promote fibrosis

Pansclerotic morphea (PSM) is a rare, devastating disease characterized by extensive soft tissue fibrosis, secondary contractions, and significant morbidity. PSM pathogenesis is unknown, and aggressive immunosuppressive treatments rarely slow disease progression. We aimed to characterize molecular m...

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Detalles Bibliográficos
Autores principales: Xing, Enze, Ma, Feiyang, Wasikowski, Rachael, Billi, Allison C., Gharaee-Kermani, Mehrnaz, Fox, Jennifer, Dobry, Craig, Victory, Amanda, Sarkar, Mrinal K., Xing, Xianying, Plazyo, Olesya, Chen, Henry W., Barber, Grant, Jacobe, Heidi, Tsou, Pei-Suen, Modlin, Robert L., Varga, John, Kahlenberg, J. Michelle, Tsoi, Lam C., Gudjonsson, Johann E., Khanna, Dinesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543736/
https://www.ncbi.nlm.nih.gov/pubmed/37471168
http://dx.doi.org/10.1172/jci.insight.171307

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