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Culture-directed antibiotics in peritoneal dialysis solutions: a systematic review focused on stability and compatibility

BACKGROUND: This systematic review summarises the stability of less commonly prescribed antibiotics in different peritoneal dialysis solutions that could be used for culture-directed therapy of peritonitis, which would be especially useful in regions with a high prevalence of multidrug antibiotic-re...

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Autores principales: Ling, Chau Wei, Sud, Kamal, Patel, Rahul, Peterson, Gregory, Wanandy, Troy, Yeoh, Siang Fei, Van, Connie, Castelino, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543841/
https://www.ncbi.nlm.nih.gov/pubmed/37548827
http://dx.doi.org/10.1007/s40620-023-01716-7
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author Ling, Chau Wei
Sud, Kamal
Patel, Rahul
Peterson, Gregory
Wanandy, Troy
Yeoh, Siang Fei
Van, Connie
Castelino, Ronald
author_facet Ling, Chau Wei
Sud, Kamal
Patel, Rahul
Peterson, Gregory
Wanandy, Troy
Yeoh, Siang Fei
Van, Connie
Castelino, Ronald
author_sort Ling, Chau Wei
collection PubMed
description BACKGROUND: This systematic review summarises the stability of less commonly prescribed antibiotics in different peritoneal dialysis solutions that could be used for culture-directed therapy of peritonitis, which would be especially useful in regions with a high prevalence of multidrug antibiotic-resistant strains. METHODS: A literature search of Medline, Scopus, Embase and Google Scholar for articles published from inception to 25 January, 2023 was conducted. Only antibiotic stability studies conducted in vitro and not recently reviewed by So et al. were included. The main outcomes were chemical, physical, antimicrobial and microbial stability. This protocol was registered in PROSPERO (registration number CRD42023393366). RESULTS: We screened 1254 abstracts, and 28 articles were included in the study. In addition to those discussed in a recent systematic review (So et al., Clin Kidney J 15(6):1071–1078, 2022), we identified 18 antimicrobial agents. Of these, 9 have intraperitoneal dosing recommendations in the recent International Society for Peritoneal Dialysis (ISPD) peritonitis guidelines, and 7 of the 9 had stability data applicable to clinical practice. They were cefotaxime, ceftriaxone, daptomycin, ofloxacin, and teicoplanin in glucose-based solutions, tobramycin in Extraneal solution only and fosfomycin in Extraneal, Nutrineal, Physioneal 1.36% and 2.27% glucose solutions. CONCLUSIONS: Physicochemical stability has not been demonstrated for all antibiotics with intraperitoneal dosing recommendations in the ISPD peritonitis guidelines. Further studies are required to determine the stability of antibiotics, especially in icodextrin-based and low-glucose degradation products, pH-neutral solutions. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40620-023-01716-7.
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spelling pubmed-105438412023-10-03 Culture-directed antibiotics in peritoneal dialysis solutions: a systematic review focused on stability and compatibility Ling, Chau Wei Sud, Kamal Patel, Rahul Peterson, Gregory Wanandy, Troy Yeoh, Siang Fei Van, Connie Castelino, Ronald J Nephrol Systematic Reviews BACKGROUND: This systematic review summarises the stability of less commonly prescribed antibiotics in different peritoneal dialysis solutions that could be used for culture-directed therapy of peritonitis, which would be especially useful in regions with a high prevalence of multidrug antibiotic-resistant strains. METHODS: A literature search of Medline, Scopus, Embase and Google Scholar for articles published from inception to 25 January, 2023 was conducted. Only antibiotic stability studies conducted in vitro and not recently reviewed by So et al. were included. The main outcomes were chemical, physical, antimicrobial and microbial stability. This protocol was registered in PROSPERO (registration number CRD42023393366). RESULTS: We screened 1254 abstracts, and 28 articles were included in the study. In addition to those discussed in a recent systematic review (So et al., Clin Kidney J 15(6):1071–1078, 2022), we identified 18 antimicrobial agents. Of these, 9 have intraperitoneal dosing recommendations in the recent International Society for Peritoneal Dialysis (ISPD) peritonitis guidelines, and 7 of the 9 had stability data applicable to clinical practice. They were cefotaxime, ceftriaxone, daptomycin, ofloxacin, and teicoplanin in glucose-based solutions, tobramycin in Extraneal solution only and fosfomycin in Extraneal, Nutrineal, Physioneal 1.36% and 2.27% glucose solutions. CONCLUSIONS: Physicochemical stability has not been demonstrated for all antibiotics with intraperitoneal dosing recommendations in the ISPD peritonitis guidelines. Further studies are required to determine the stability of antibiotics, especially in icodextrin-based and low-glucose degradation products, pH-neutral solutions. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40620-023-01716-7. Springer International Publishing 2023-08-07 2023 /pmc/articles/PMC10543841/ /pubmed/37548827 http://dx.doi.org/10.1007/s40620-023-01716-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Systematic Reviews
Ling, Chau Wei
Sud, Kamal
Patel, Rahul
Peterson, Gregory
Wanandy, Troy
Yeoh, Siang Fei
Van, Connie
Castelino, Ronald
Culture-directed antibiotics in peritoneal dialysis solutions: a systematic review focused on stability and compatibility
title Culture-directed antibiotics in peritoneal dialysis solutions: a systematic review focused on stability and compatibility
title_full Culture-directed antibiotics in peritoneal dialysis solutions: a systematic review focused on stability and compatibility
title_fullStr Culture-directed antibiotics in peritoneal dialysis solutions: a systematic review focused on stability and compatibility
title_full_unstemmed Culture-directed antibiotics in peritoneal dialysis solutions: a systematic review focused on stability and compatibility
title_short Culture-directed antibiotics in peritoneal dialysis solutions: a systematic review focused on stability and compatibility
title_sort culture-directed antibiotics in peritoneal dialysis solutions: a systematic review focused on stability and compatibility
topic Systematic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543841/
https://www.ncbi.nlm.nih.gov/pubmed/37548827
http://dx.doi.org/10.1007/s40620-023-01716-7
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