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Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain

BACKGROUND: Immunosuppression induced by programmed cell death protein 1 (PD1) presents a significant constraint on the effectiveness of chimeric antigen receptor (CAR)-T therapy. The potential of combining PD1/PDL1 (Programmed cell death 1 ligand 1) axis blockade with CAR-T cell therapy is promisin...

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Detalles Bibliográficos
Autores principales:	Zhang, Ang, Wang, Shenyu, Sun, Yao, Zhang, Yikun, Zhao, Long, Yang, Yang, Zhang, Yijian, Xu, Lei, Lei, Yangyang, Du, Jie, Chen, Hu, Duan, Lian, He, Mingyi, Shi, Lintao, Liu, Lei, Wang, Quanjun, Hu, Liangding, Zhang, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543853/ https://www.ncbi.nlm.nih.gov/pubmed/37777797 http://dx.doi.org/10.1186/s40164-023-00438-7

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