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Hierarchical Phosphorylation of HOXB13 by mTOR Dictates Its Activity and Oncogenic Function in Prostate Cancer

Dysregulation of mTOR signaling plays a critical role in promoting prostate cancer growth. HOXB13, a homeodomain transcription factor, is known to influence the androgen response and prostate cancer development. Recently, HOXB13 was found to complex with mTOR on chromatin. However, the functional cr...

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Detalles Bibliográficos
Autores principales:	Chen, Yonghong, Dufour, Catherine R., Han, Lingwei, Li, Ting, Xia, Hui, Giguère, Vincent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Cancer Genes and Networks
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544006/ https://www.ncbi.nlm.nih.gov/pubmed/37409967 http://dx.doi.org/10.1158/1541-7786.MCR-23-0086

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