Structure-Based Design and Synthesis of Stapled (10)Panx1 Analogues for Use in Cardiovascular Inflammatory Diseases

[Image: see text] Following a rational design, a series of macrocyclic (“stapled”) peptidomimetics of (10)Panx1, the most established peptide inhibitor of Pannexin1 (Panx1) channels, were developed and synthesized. Two macrocyclic analogues SBL-PX1-42 and SBL-PX1-44 outperformed the linear native pe...

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Detalles Bibliográficos
Autores principales: Lamouroux, Arthur, Tournier, Malaury, Iaculli, Debora, Caufriez, Anne, Rusiecka, Olga M., Martin, Charlotte, Bes, Viviane, Carpio, Laureano E., Girardin, Yana, Loris, Remy, Tabernilla, Andrés, Molica, Filippo, Gozalbes, Rafael, Mayán, María D., Vinken, Mathieu, Kwak, Brenda R., Ballet, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544015/
https://www.ncbi.nlm.nih.gov/pubmed/37703077
http://dx.doi.org/10.1021/acs.jmedchem.3c01116

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