Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2

[Image: see text] The inhibition of CXC chemokine receptor 2 (CXCR2), a key inflammatory mediator, is a potential strategy in the treatment of several pulmonary diseases and cancers. The complexity of endogenous chemokine interaction with the orthosteric binding site has led to the development of CX...

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Autores principales: Casella, Bianca Maria, Farmer, James P., Nesheva, Desislava N., Williams, Huw E. L., Charlton, Steven J., Holliday, Nicholas D., Laughton, Charles A., Mistry, Shailesh N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544029/
https://www.ncbi.nlm.nih.gov/pubmed/37523859
http://dx.doi.org/10.1021/acs.jmedchem.3c00849

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