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Factors related to the presence of nonalcoholic fatty liver disease in patients with type 2 diabetes: a single center study

AIM OF THE STUDY: There is a close relationship between the development of diabetes and nonalcoholic fatty liver disease (NAFLD). The aim of the study was to determine the frequency and associated factors of NAFLD in type 2 diabetes mellitus (T2DM) patients according to the ultrasound examination an...

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Autores principales: Akin, Seydahmet, Gungor, Oguzhan, Boyuk, Banu, Erman, Hande
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544059/
https://www.ncbi.nlm.nih.gov/pubmed/37790683
http://dx.doi.org/10.5114/ceh.2023.130665
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author Akin, Seydahmet
Gungor, Oguzhan
Boyuk, Banu
Erman, Hande
author_facet Akin, Seydahmet
Gungor, Oguzhan
Boyuk, Banu
Erman, Hande
author_sort Akin, Seydahmet
collection PubMed
description AIM OF THE STUDY: There is a close relationship between the development of diabetes and nonalcoholic fatty liver disease (NAFLD). The aim of the study was to determine the frequency and associated factors of NAFLD in type 2 diabetes mellitus (T2DM) patients according to the ultrasound examination and noninvasive hepatic fibrosis indices. MATERIAL AND METHODS: 316 patients who were followed up in the Internal Medicine Diabetes clinic, over the age of 18, diagnosed with T2DM were included retrospectively. NAFLD was noted using ultrasound. NAFLD fibrosis score (NFS), fibrosis-4 index (FIB-4) and AST to platelet ratio index (APRI) were used as non-invasive hepatic fibrosis indices. RESULTS: The prevalence of NAFLD with hepatic ultrasound was 89.7% in T2DM patients. Among non-invasive fibrosis indices, NFS and FIB-4 were similar, but APRI was significantly higher in moderate-severe hepatosteatosis group (p values = 0.355, 0.246 and 0.003 respectively). In logistic regression analysis, while mild hepatosteatosis was associated with BMI and NFS (p = 0.004, p = 0.008), moderate to severe hepatosteatosis as associated with BMI and serum triglycerides (p < 0.001, p = 0.019). CONCLUSIONS: The prevalence of NAFLD is high in patients with T2DM. The frequency and degree of NAFLD is associated with the NFS, BMI and hypertriglyceridemia. While NFS is associated with mild hepatosteatosis; moderate to severe hepatosteatosis is associated with BMI and serum triglycerides.
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spelling pubmed-105440592023-10-03 Factors related to the presence of nonalcoholic fatty liver disease in patients with type 2 diabetes: a single center study Akin, Seydahmet Gungor, Oguzhan Boyuk, Banu Erman, Hande Clin Exp Hepatol Original Paper AIM OF THE STUDY: There is a close relationship between the development of diabetes and nonalcoholic fatty liver disease (NAFLD). The aim of the study was to determine the frequency and associated factors of NAFLD in type 2 diabetes mellitus (T2DM) patients according to the ultrasound examination and noninvasive hepatic fibrosis indices. MATERIAL AND METHODS: 316 patients who were followed up in the Internal Medicine Diabetes clinic, over the age of 18, diagnosed with T2DM were included retrospectively. NAFLD was noted using ultrasound. NAFLD fibrosis score (NFS), fibrosis-4 index (FIB-4) and AST to platelet ratio index (APRI) were used as non-invasive hepatic fibrosis indices. RESULTS: The prevalence of NAFLD with hepatic ultrasound was 89.7% in T2DM patients. Among non-invasive fibrosis indices, NFS and FIB-4 were similar, but APRI was significantly higher in moderate-severe hepatosteatosis group (p values = 0.355, 0.246 and 0.003 respectively). In logistic regression analysis, while mild hepatosteatosis was associated with BMI and NFS (p = 0.004, p = 0.008), moderate to severe hepatosteatosis as associated with BMI and serum triglycerides (p < 0.001, p = 0.019). CONCLUSIONS: The prevalence of NAFLD is high in patients with T2DM. The frequency and degree of NAFLD is associated with the NFS, BMI and hypertriglyceridemia. While NFS is associated with mild hepatosteatosis; moderate to severe hepatosteatosis is associated with BMI and serum triglycerides. Termedia Publishing House 2023-09-06 2023-09 /pmc/articles/PMC10544059/ /pubmed/37790683 http://dx.doi.org/10.5114/ceh.2023.130665 Text en Copyright © 2023 Clinical and Experimental Hepatology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) )
spellingShingle Original Paper
Akin, Seydahmet
Gungor, Oguzhan
Boyuk, Banu
Erman, Hande
Factors related to the presence of nonalcoholic fatty liver disease in patients with type 2 diabetes: a single center study
title Factors related to the presence of nonalcoholic fatty liver disease in patients with type 2 diabetes: a single center study
title_full Factors related to the presence of nonalcoholic fatty liver disease in patients with type 2 diabetes: a single center study
title_fullStr Factors related to the presence of nonalcoholic fatty liver disease in patients with type 2 diabetes: a single center study
title_full_unstemmed Factors related to the presence of nonalcoholic fatty liver disease in patients with type 2 diabetes: a single center study
title_short Factors related to the presence of nonalcoholic fatty liver disease in patients with type 2 diabetes: a single center study
title_sort factors related to the presence of nonalcoholic fatty liver disease in patients with type 2 diabetes: a single center study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544059/
https://www.ncbi.nlm.nih.gov/pubmed/37790683
http://dx.doi.org/10.5114/ceh.2023.130665
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