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Carbonic anhydrase mimics with rationally designed active sites for fine-tuned catalytic activity and selectivity in ester hydrolysis

Numerous hydrolytic enzymes utilize zinc as a cofactor for catalysis. We here report water-soluble polymeric nanoparticles with zinc ions in active sites and a nearby base as a mimic of carbonic anhydrase (CA). Their pK(a) of 6.3–6.4 for zinc-bound water is lower than the 6.8–7.3 value for natural e...

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Detalles Bibliográficos
Autores principales: Bahrami, Foroogh, Zhao, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544069/
https://www.ncbi.nlm.nih.gov/pubmed/38013842
http://dx.doi.org/10.1039/d3cy00704a

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