PCSK9 Promotes Hypoxia-Induced EC Pyroptosis by Regulating Smac Mitochondrion-Cytoplasm Translocation in Critical Limb Ischemia

Hypoxia-induced endothelial cell death and impaired angiogenesis are the main pathophysiological features of critical limb ischemia. Mechanistically, proprotein convertase subtilisin/kexin type 9 (PCSK9) promoted Smac translocation from mitochondria to the cytoplasm. Inhibition of Smac release into...

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Detalles Bibliográficos
Autores principales: Zhang, Meixin, Chen, Yixi, Qiu, Yumin, Sun, Jiapan, He, Jiang, Liu, Zhefu, Shi, Jian, Wei, Wenbin, Wu, Guifu, Liang, Jianwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Leading Edge Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544082/
https://www.ncbi.nlm.nih.gov/pubmed/37791316
http://dx.doi.org/10.1016/j.jacbts.2023.05.016

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