The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma

Head and neck squamous cell carcinoma (HNSCC), which originates in the head or neck tissues, is characterized by high rates of recurrence and metastasis. Inflammation is important in HNSCC prognosis. Inflammatory cells and their secreted factors contribute to the various stages of HNSCC development...

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Detalles Bibliográficos
Autores principales: Li, Kang, Zeng, Xianhai, Liu, Peng, Zeng, Xiaoxia, Lv, Jie, Qiu, Shuqi, Zhang, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544098/
https://www.ncbi.nlm.nih.gov/pubmed/37791117
http://dx.doi.org/10.2147/JIR.S428358
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author Li, Kang
Zeng, Xianhai
Liu, Peng
Zeng, Xiaoxia
Lv, Jie
Qiu, Shuqi
Zhang, Peng
author_facet Li, Kang
Zeng, Xianhai
Liu, Peng
Zeng, Xiaoxia
Lv, Jie
Qiu, Shuqi
Zhang, Peng
author_sort Li, Kang
collection PubMed
description Head and neck squamous cell carcinoma (HNSCC), which originates in the head or neck tissues, is characterized by high rates of recurrence and metastasis. Inflammation is important in HNSCC prognosis. Inflammatory cells and their secreted factors contribute to the various stages of HNSCC development through multiple mechanisms. In this review, the mechanisms through which inflammatory factors, signaling pathways, and cells contribute to the initiation and progression of HNSCC have been discussed in detail. Furthermore, the diagnostic and therapeutic potential of targeting inflammation in HNSCC has been discussed to gain new insights into improving patient prognosis.
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spelling pubmed-105440982023-10-03 The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma Li, Kang Zeng, Xianhai Liu, Peng Zeng, Xiaoxia Lv, Jie Qiu, Shuqi Zhang, Peng J Inflamm Res Review Head and neck squamous cell carcinoma (HNSCC), which originates in the head or neck tissues, is characterized by high rates of recurrence and metastasis. Inflammation is important in HNSCC prognosis. Inflammatory cells and their secreted factors contribute to the various stages of HNSCC development through multiple mechanisms. In this review, the mechanisms through which inflammatory factors, signaling pathways, and cells contribute to the initiation and progression of HNSCC have been discussed in detail. Furthermore, the diagnostic and therapeutic potential of targeting inflammation in HNSCC has been discussed to gain new insights into improving patient prognosis. Dove 2023-09-27 /pmc/articles/PMC10544098/ /pubmed/37791117 http://dx.doi.org/10.2147/JIR.S428358 Text en © 2023 Li et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Li, Kang
Zeng, Xianhai
Liu, Peng
Zeng, Xiaoxia
Lv, Jie
Qiu, Shuqi
Zhang, Peng
The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma
title The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma
title_full The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma
title_fullStr The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma
title_full_unstemmed The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma
title_short The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma
title_sort role of inflammation-associated factors in head and neck squamous cell carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544098/
https://www.ncbi.nlm.nih.gov/pubmed/37791117
http://dx.doi.org/10.2147/JIR.S428358
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