Argininosuccinate lyase deficiency causes blood-brain barrier disruption via nitric oxide–mediated dysregulation of claudin expression

Nitric oxide (NO) is a critical signaling molecule that has been implicated in the pathogenesis of neurocognitive diseases. Both excessive and insufficient NO production have been linked to pathology. Previously, we have shown that argininosuccinate lyase deficiency (ASLD) is a novel model system to...

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Detalles Bibliográficos
Autores principales: Kho, Jordan, Polak, Urszula, Jiang, Ming-Ming, Odom, John D., Hunter, Jill V., Ali, Saima M., Burrage, Lindsay C., Nagamani, Sandesh C.S., Pautler, Robia G., Thompson, Hannah P., Urayama, Akihiko, Jin, Zixue, Lee, Brendan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544197/
https://www.ncbi.nlm.nih.gov/pubmed/37490345
http://dx.doi.org/10.1172/jci.insight.168475

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