DNASE1L3 enhances antitumor immunity and suppresses tumor progression in colon cancer

DNASE1L3, an enzyme highly expressed in DCs, is functionally important for regulating autoimmune responses to self-DNA and chromatin. Deficiency of DNASE1L3 leads to development of autoimmune diseases in both humans and mice. However, despite the well-established causal relationship between DNASE1L3...

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Detalles Bibliográficos
Autores principales: Li, Wenling, Nakano, Hideki, Fan, Wei, Li, Yuanyuan, Sil, Payel, Nakano, Keiko, Zhao, Fei, Karmaus, Peer W., Grimm, Sara A., Shi, Min, Xu, Xin, Mizuta, Ryushin, Kitamura, Daisuke, Wan, Yisong, Fessler, Michael B., Cook, Donald N., Shats, Igor, Li, Xiaoling, Li, Leping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544201/
https://www.ncbi.nlm.nih.gov/pubmed/37581941
http://dx.doi.org/10.1172/jci.insight.168161

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