Single-cell transcriptome analysis and protein profiling reveal broad immune system activation in IgG4-related disease

IgG4-related disease (IgG4-RD) is a systemic autoimmune disease with unclear pathogenesis. We performed single-cell RNA-seq and surface proteome analyses on 61,379 PBMCs from 9 treatment-naive IgG4-RD patients and 7 age- and sex-matched healthy controls. Integrative analyses were performed for alter...

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Detalles Bibliográficos
Autores principales: Lu, Chenyang, Li, Shasha, Qing, Pingying, Zhang, Qiuping, Ji, Xing, Tang, Zhigang, Chen, Chunyan, Wu, Tong, Hu, Yidan, Zhao, Yi, Zhang, Xiaohui, He, Qi, Fox, David A., Tan, Chunyu, Luo, Yubin, Liu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544205/
https://www.ncbi.nlm.nih.gov/pubmed/37561593
http://dx.doi.org/10.1172/jci.insight.167602

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