Role of non-canonical post-translational modifications in gastrointestinal tumors

Post-translational modifications (PTMs) of proteins contribute to the occurrence and development of tumors. Previous studies have suggested that canonical PTMs such as ubiquitination, glycosylation, and phosphorylation are closely implicated in different aspects of gastrointestinal tumors. Recently,...

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Autores principales: Liu, Yihong, Liu, Jingwei, Peng, Na, Hai, Shuangshuang, Zhang, Shen, Zhao, Haibo, Liu, Weixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544213/
https://www.ncbi.nlm.nih.gov/pubmed/37777749
http://dx.doi.org/10.1186/s12935-023-03062-x
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author Liu, Yihong
Liu, Jingwei
Peng, Na
Hai, Shuangshuang
Zhang, Shen
Zhao, Haibo
Liu, Weixin
author_facet Liu, Yihong
Liu, Jingwei
Peng, Na
Hai, Shuangshuang
Zhang, Shen
Zhao, Haibo
Liu, Weixin
author_sort Liu, Yihong
collection PubMed
description Post-translational modifications (PTMs) of proteins contribute to the occurrence and development of tumors. Previous studies have suggested that canonical PTMs such as ubiquitination, glycosylation, and phosphorylation are closely implicated in different aspects of gastrointestinal tumors. Recently, emerging evidence showed that non-canonical PTMs play an essential role in the carcinogenesis, metastasis and treatment of gastrointestinal tumors. Therefore, we summarized recent advances in sumoylation, neddylation, isoprenylation, succinylation and other non-canonical PTMs in gastrointestinal tumors, which comprehensively describe the mechanisms and functions of non-classical PTMs in gastrointestinal tumors. It is anticipated that targeting specific PTMs could benefit the treatment as well as improve the prognosis of gastrointestinal tumors.
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spelling pubmed-105442132023-10-03 Role of non-canonical post-translational modifications in gastrointestinal tumors Liu, Yihong Liu, Jingwei Peng, Na Hai, Shuangshuang Zhang, Shen Zhao, Haibo Liu, Weixin Cancer Cell Int Review Post-translational modifications (PTMs) of proteins contribute to the occurrence and development of tumors. Previous studies have suggested that canonical PTMs such as ubiquitination, glycosylation, and phosphorylation are closely implicated in different aspects of gastrointestinal tumors. Recently, emerging evidence showed that non-canonical PTMs play an essential role in the carcinogenesis, metastasis and treatment of gastrointestinal tumors. Therefore, we summarized recent advances in sumoylation, neddylation, isoprenylation, succinylation and other non-canonical PTMs in gastrointestinal tumors, which comprehensively describe the mechanisms and functions of non-classical PTMs in gastrointestinal tumors. It is anticipated that targeting specific PTMs could benefit the treatment as well as improve the prognosis of gastrointestinal tumors. BioMed Central 2023-09-30 /pmc/articles/PMC10544213/ /pubmed/37777749 http://dx.doi.org/10.1186/s12935-023-03062-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Liu, Yihong
Liu, Jingwei
Peng, Na
Hai, Shuangshuang
Zhang, Shen
Zhao, Haibo
Liu, Weixin
Role of non-canonical post-translational modifications in gastrointestinal tumors
title Role of non-canonical post-translational modifications in gastrointestinal tumors
title_full Role of non-canonical post-translational modifications in gastrointestinal tumors
title_fullStr Role of non-canonical post-translational modifications in gastrointestinal tumors
title_full_unstemmed Role of non-canonical post-translational modifications in gastrointestinal tumors
title_short Role of non-canonical post-translational modifications in gastrointestinal tumors
title_sort role of non-canonical post-translational modifications in gastrointestinal tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544213/
https://www.ncbi.nlm.nih.gov/pubmed/37777749
http://dx.doi.org/10.1186/s12935-023-03062-x
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