Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations

Pathogenic mutations in mitochondrial (mt) tRNA genes that compromise oxidative phosphorylation (OXPHOS) exhibit heteroplasmy and cause a range of multisyndromic conditions. Although mitochondrial disease patients are known to suffer from abnormal immune responses, how heteroplasmic mtDNA mutations...

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Detalles Bibliográficos
Autores principales: Zhang, Jingdian, Koolmeister, Camilla, Han, Jinming, Filograna, Roberta, Hanke, Leo, Àdori, Monika, Sheward, Daniel J., Teifel, Sina, Gopalakrishna, Shreekara, Shao, Qiuya, Liu, Yong, Zhu, Keying, Harris, Robert A., McInerney, Gerald, Murrell, Ben, Aoun, Mike, Bäckdahl, Liselotte, Holmdahl, Rikard, Pekalski, Marcin, Wedell, Anna, Engvall, Martin, Wredenberg, Anna, Karlsson Hedestam, Gunilla B., Castro Dopico, Xaquin, Rorbach, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544217/
https://www.ncbi.nlm.nih.gov/pubmed/37681412
http://dx.doi.org/10.1172/jci.insight.167656

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