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Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation

A T50I substitution in the K-Ras interswitch domain causes Noonan syndrome and emerged as a third-site mutation that restored the in vivo transforming activity and constitutive MAPK pathway activation by an attenuated Kras(G12D,E37G) oncogene in a mouse leukemia model. Biochemical and crystallograph...

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Detalles Bibliográficos
Autores principales:	Chen, Pan-Yu, Huang, Benjamin J., Harris, Max, Boone, Christopher, Wang, Weijie, Carias, Heidi, Mesiona, Brian, Mavrici, Daniela, Kohler, Amanda C., Bollag, Gideon, Zhang, Chao, Zhang, Ying, Shannon, Kevin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544224/ https://www.ncbi.nlm.nih.gov/pubmed/37681415 http://dx.doi.org/10.1172/jci.insight.168445

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