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Decoding the role of gut microbiota in Alzheimer’s pathogenesis and envisioning future therapeutic avenues

Alzheimer’s disease (AD) emerges as a perturbing neurodegenerative malady, with a profound comprehension of its underlying pathogenic mechanisms continuing to evade our intellectual grasp. Within the intricate tapestry of human health and affliction, the enteric microbial consortium, ensconced withi...

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Autores principales: Liang, Junyi, Liu, Bin, Dong, Xiaohong, Wang, Yueyang, Cai, Wenhui, Zhang, Ning, Zhang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544353/
https://www.ncbi.nlm.nih.gov/pubmed/37790586
http://dx.doi.org/10.3389/fnins.2023.1242254
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author Liang, Junyi
Liu, Bin
Dong, Xiaohong
Wang, Yueyang
Cai, Wenhui
Zhang, Ning
Zhang, Hong
author_facet Liang, Junyi
Liu, Bin
Dong, Xiaohong
Wang, Yueyang
Cai, Wenhui
Zhang, Ning
Zhang, Hong
author_sort Liang, Junyi
collection PubMed
description Alzheimer’s disease (AD) emerges as a perturbing neurodegenerative malady, with a profound comprehension of its underlying pathogenic mechanisms continuing to evade our intellectual grasp. Within the intricate tapestry of human health and affliction, the enteric microbial consortium, ensconced within the milieu of the human gastrointestinal tract, assumes a role of cardinal significance. Recent epochs have borne witness to investigations that posit marked divergences in the composition of the gut microbiota between individuals grappling with AD and those favored by robust health. The composite vicissitudes in the configuration of the enteric microbial assembly are posited to choreograph a participatory role in the inception and progression of AD, facilitated by the intricate conduit acknowledged as the gut-brain axis. Notwithstanding, the precise nature of this interlaced relationship remains enshrouded within the recesses of obscurity, poised for an exhaustive revelation. This review embarks upon the endeavor to focalize meticulously upon the mechanistic sway exerted by the enteric microbiota upon AD, plunging profoundly into the execution of interventions that govern the milieu of enteric microorganisms. In doing so, it bestows relevance upon the therapeutic stratagems that form the bedrock of AD’s management, all whilst casting a prospective gaze into the horizon of medical advancements.
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spelling pubmed-105443532023-10-03 Decoding the role of gut microbiota in Alzheimer’s pathogenesis and envisioning future therapeutic avenues Liang, Junyi Liu, Bin Dong, Xiaohong Wang, Yueyang Cai, Wenhui Zhang, Ning Zhang, Hong Front Neurosci Neuroscience Alzheimer’s disease (AD) emerges as a perturbing neurodegenerative malady, with a profound comprehension of its underlying pathogenic mechanisms continuing to evade our intellectual grasp. Within the intricate tapestry of human health and affliction, the enteric microbial consortium, ensconced within the milieu of the human gastrointestinal tract, assumes a role of cardinal significance. Recent epochs have borne witness to investigations that posit marked divergences in the composition of the gut microbiota between individuals grappling with AD and those favored by robust health. The composite vicissitudes in the configuration of the enteric microbial assembly are posited to choreograph a participatory role in the inception and progression of AD, facilitated by the intricate conduit acknowledged as the gut-brain axis. Notwithstanding, the precise nature of this interlaced relationship remains enshrouded within the recesses of obscurity, poised for an exhaustive revelation. This review embarks upon the endeavor to focalize meticulously upon the mechanistic sway exerted by the enteric microbiota upon AD, plunging profoundly into the execution of interventions that govern the milieu of enteric microorganisms. In doing so, it bestows relevance upon the therapeutic stratagems that form the bedrock of AD’s management, all whilst casting a prospective gaze into the horizon of medical advancements. Frontiers Media S.A. 2023-09-18 /pmc/articles/PMC10544353/ /pubmed/37790586 http://dx.doi.org/10.3389/fnins.2023.1242254 Text en Copyright © 2023 Liang, Liu, Dong, Wang, Cai, Zhang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Liang, Junyi
Liu, Bin
Dong, Xiaohong
Wang, Yueyang
Cai, Wenhui
Zhang, Ning
Zhang, Hong
Decoding the role of gut microbiota in Alzheimer’s pathogenesis and envisioning future therapeutic avenues
title Decoding the role of gut microbiota in Alzheimer’s pathogenesis and envisioning future therapeutic avenues
title_full Decoding the role of gut microbiota in Alzheimer’s pathogenesis and envisioning future therapeutic avenues
title_fullStr Decoding the role of gut microbiota in Alzheimer’s pathogenesis and envisioning future therapeutic avenues
title_full_unstemmed Decoding the role of gut microbiota in Alzheimer’s pathogenesis and envisioning future therapeutic avenues
title_short Decoding the role of gut microbiota in Alzheimer’s pathogenesis and envisioning future therapeutic avenues
title_sort decoding the role of gut microbiota in alzheimer’s pathogenesis and envisioning future therapeutic avenues
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544353/
https://www.ncbi.nlm.nih.gov/pubmed/37790586
http://dx.doi.org/10.3389/fnins.2023.1242254
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