Strike Out: A Case Report of Glioblastoma in a Collegiate Softball Player

A 20-year-old female, right-hand-dominant Division I softball player, presented to her pre-participation exam endorsing numbness that started in her left thumb and had progressed to involve her entire hand and left medial elbow. She had no change in her physical health over the past year prior to presentation and denied injury illness or trauma to the left upper extremity or neck. She reported no change in her softball off-season training regimen or equipment. Exam exhibited decreased sensation in C6, C7, and C8 dermatomes and weakness in the C8 myotome. Magnetic resonance angiography (MRA) displayed a right parietal lobe mass which biopsy confirmed as glioblastoma multiforme (GBM). GBM, also known as glioblastoma or grade 4 astrocytoma is an aggressive form of cancer that can affect the brain and spinal cord. Despite being the most common malignant primary brain tumor in adults, current treatment is mostly palliative. Treatment for this student-athlete included surgery, radiation, and chemotherapy. The selection of aggressive treatment including excision of the tumor was largely elected due to her age. She received chemotherapy with temozolomide in conjunction with radiation for a total of nine months. Following treatment, she worked with physical therapy to help improve her functional deficits, caused both by the tumor as well as the excision. Additionally, psychological and emotional support was provided to the patient during the course of the diagnosis and treatment of her athletics career-ending diagnosis. The same support services were also extended to the entirety of her teammates as well as her family members. This case outlines the diagnosis, treatment, and challenges of GBM in a Division I softball athlete including the challenges of providing emotional support for an athlete living away from home while being diagnosed with a life and athletics-career altering condition.