Cargando…
Hyperlipidemia in immune thrombocytopenia: a retrospective study
BACKGROUND: Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by low platelet count and bleeding manifestations. However, some patients also suffered from atherosclerosis or even infarction. Apart from activated platelets, lipid metabolism takes a large part in the for...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544441/ https://www.ncbi.nlm.nih.gov/pubmed/37784127 http://dx.doi.org/10.1186/s12959-023-00545-9 |
_version_ | 1785114505078898688 |
---|---|
author | Han, Shouqing Lu, Hui Yu, Yafei Liu, Xinguang Jing, Fangmiao Wang, Liang Zhao, Yajing Hou, Ming |
author_facet | Han, Shouqing Lu, Hui Yu, Yafei Liu, Xinguang Jing, Fangmiao Wang, Liang Zhao, Yajing Hou, Ming |
author_sort | Han, Shouqing |
collection | PubMed |
description | BACKGROUND: Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by low platelet count and bleeding manifestations. However, some patients also suffered from atherosclerosis or even infarction. Apart from activated platelets, lipid metabolism takes a large part in the formation of atherosclerosis and metabolic syndrome. The lipid metabolic state in ITP patients is still unknown. METHODS: We retrospectively reviewed 302 hospitalized ITP patients in our cohort, comparing their blood lipids, bleeding symptoms, metabolic diseases and treatment responses. RESULTS: We found a high proportion of ITP patients suffered from hyperlipidemia, and other metabolic diseases including cardiovascular or cerebral atherosclerosis or infarction, hypertension, and type 2 diabetes. Hyperlipidemia was associated with severe bleeding and treatment refractoriness in ITP. Statins could alleviate thrombocytopenia and bleeding severity, and facilitate ITP treatment, while improving hyperlipidemia in ITP patients. CONCLUSIONS: Our present study demonstrated that lipid metabolism might play an indispensable role in ITP pathogenesis and development. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12959-023-00545-9. |
format | Online Article Text |
id | pubmed-10544441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105444412023-10-03 Hyperlipidemia in immune thrombocytopenia: a retrospective study Han, Shouqing Lu, Hui Yu, Yafei Liu, Xinguang Jing, Fangmiao Wang, Liang Zhao, Yajing Hou, Ming Thromb J Research BACKGROUND: Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by low platelet count and bleeding manifestations. However, some patients also suffered from atherosclerosis or even infarction. Apart from activated platelets, lipid metabolism takes a large part in the formation of atherosclerosis and metabolic syndrome. The lipid metabolic state in ITP patients is still unknown. METHODS: We retrospectively reviewed 302 hospitalized ITP patients in our cohort, comparing their blood lipids, bleeding symptoms, metabolic diseases and treatment responses. RESULTS: We found a high proportion of ITP patients suffered from hyperlipidemia, and other metabolic diseases including cardiovascular or cerebral atherosclerosis or infarction, hypertension, and type 2 diabetes. Hyperlipidemia was associated with severe bleeding and treatment refractoriness in ITP. Statins could alleviate thrombocytopenia and bleeding severity, and facilitate ITP treatment, while improving hyperlipidemia in ITP patients. CONCLUSIONS: Our present study demonstrated that lipid metabolism might play an indispensable role in ITP pathogenesis and development. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12959-023-00545-9. BioMed Central 2023-10-02 /pmc/articles/PMC10544441/ /pubmed/37784127 http://dx.doi.org/10.1186/s12959-023-00545-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Han, Shouqing Lu, Hui Yu, Yafei Liu, Xinguang Jing, Fangmiao Wang, Liang Zhao, Yajing Hou, Ming Hyperlipidemia in immune thrombocytopenia: a retrospective study |
title | Hyperlipidemia in immune thrombocytopenia: a retrospective study |
title_full | Hyperlipidemia in immune thrombocytopenia: a retrospective study |
title_fullStr | Hyperlipidemia in immune thrombocytopenia: a retrospective study |
title_full_unstemmed | Hyperlipidemia in immune thrombocytopenia: a retrospective study |
title_short | Hyperlipidemia in immune thrombocytopenia: a retrospective study |
title_sort | hyperlipidemia in immune thrombocytopenia: a retrospective study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544441/ https://www.ncbi.nlm.nih.gov/pubmed/37784127 http://dx.doi.org/10.1186/s12959-023-00545-9 |
work_keys_str_mv | AT hanshouqing hyperlipidemiainimmunethrombocytopeniaaretrospectivestudy AT luhui hyperlipidemiainimmunethrombocytopeniaaretrospectivestudy AT yuyafei hyperlipidemiainimmunethrombocytopeniaaretrospectivestudy AT liuxinguang hyperlipidemiainimmunethrombocytopeniaaretrospectivestudy AT jingfangmiao hyperlipidemiainimmunethrombocytopeniaaretrospectivestudy AT wangliang hyperlipidemiainimmunethrombocytopeniaaretrospectivestudy AT zhaoyajing hyperlipidemiainimmunethrombocytopeniaaretrospectivestudy AT houming hyperlipidemiainimmunethrombocytopeniaaretrospectivestudy |