Roles of Twist1 in lipid and glucose metabolism

The abnormal lipid and glucose metabolisms are linked to the metabolic disorders, tumorigenesis, and fibrotic diseases, which attracts the increasing attention to find out the key molecules involved in the lipid and glucose metabolism as the possible therapeutic targets on these diseases. A transcri...

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Autores principales: Huang, Liuyifei, Xing, Yan, Ning, Xiaoxuan, Yu, Zhixiang, Bai, Xiao, Liu, Limin, Sun, Shiren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544448/
https://www.ncbi.nlm.nih.gov/pubmed/37784111
http://dx.doi.org/10.1186/s12964-023-01262-6
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author Huang, Liuyifei
Xing, Yan
Ning, Xiaoxuan
Yu, Zhixiang
Bai, Xiao
Liu, Limin
Sun, Shiren
author_facet Huang, Liuyifei
Xing, Yan
Ning, Xiaoxuan
Yu, Zhixiang
Bai, Xiao
Liu, Limin
Sun, Shiren
author_sort Huang, Liuyifei
collection PubMed
description The abnormal lipid and glucose metabolisms are linked to the metabolic disorders, tumorigenesis, and fibrotic diseases, which attracts the increasing attention to find out the key molecules involved in the lipid and glucose metabolism as the possible therapeutic targets on these diseases. A transcriptional factor Twist1 has been associated with not only the embryonic development, cancer, and fibrotic diseases, but also the regulation of lipid and glucose metabolism. In this review, we will discuss the roles and mechanisms of Twist1 in the obesity-associated white adipose tissue inflammation and insulin resistance, brown adipose tissue metabolism, fatty acid oxidation, and glucose metabolism in skeletal muscle to provide a rational perspective to consider Twist1 as a potential treatment target in clinic. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01262-6.
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spelling pubmed-105444482023-10-03 Roles of Twist1 in lipid and glucose metabolism Huang, Liuyifei Xing, Yan Ning, Xiaoxuan Yu, Zhixiang Bai, Xiao Liu, Limin Sun, Shiren Cell Commun Signal Review The abnormal lipid and glucose metabolisms are linked to the metabolic disorders, tumorigenesis, and fibrotic diseases, which attracts the increasing attention to find out the key molecules involved in the lipid and glucose metabolism as the possible therapeutic targets on these diseases. A transcriptional factor Twist1 has been associated with not only the embryonic development, cancer, and fibrotic diseases, but also the regulation of lipid and glucose metabolism. In this review, we will discuss the roles and mechanisms of Twist1 in the obesity-associated white adipose tissue inflammation and insulin resistance, brown adipose tissue metabolism, fatty acid oxidation, and glucose metabolism in skeletal muscle to provide a rational perspective to consider Twist1 as a potential treatment target in clinic. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01262-6. BioMed Central 2023-10-02 /pmc/articles/PMC10544448/ /pubmed/37784111 http://dx.doi.org/10.1186/s12964-023-01262-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Huang, Liuyifei
Xing, Yan
Ning, Xiaoxuan
Yu, Zhixiang
Bai, Xiao
Liu, Limin
Sun, Shiren
Roles of Twist1 in lipid and glucose metabolism
title Roles of Twist1 in lipid and glucose metabolism
title_full Roles of Twist1 in lipid and glucose metabolism
title_fullStr Roles of Twist1 in lipid and glucose metabolism
title_full_unstemmed Roles of Twist1 in lipid and glucose metabolism
title_short Roles of Twist1 in lipid and glucose metabolism
title_sort roles of twist1 in lipid and glucose metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544448/
https://www.ncbi.nlm.nih.gov/pubmed/37784111
http://dx.doi.org/10.1186/s12964-023-01262-6
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AT yuzhixiang rolesoftwist1inlipidandglucosemetabolism
AT baixiao rolesoftwist1inlipidandglucosemetabolism
AT liulimin rolesoftwist1inlipidandglucosemetabolism
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