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Amniotic membrane and/or umbilical cord tissue for treatment of facet joint syndrome: a narrative review
Musculoskeletal spine disorders, especially low back pain, induce enormous amounts of stress and financial burden on individuals and healthcare systems throughout the world. Disorders of the facet joints in the lumbar spine are the most predominant cause of back pain, resulting in facet joint syndro...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544465/ https://www.ncbi.nlm.nih.gov/pubmed/37784162 http://dx.doi.org/10.1186/s13018-023-04241-2 |
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author | Gupta, Ashim Maffulli, Nicola |
author_facet | Gupta, Ashim Maffulli, Nicola |
author_sort | Gupta, Ashim |
collection | PubMed |
description | Musculoskeletal spine disorders, especially low back pain, induce enormous amounts of stress and financial burden on individuals and healthcare systems throughout the world. Disorders of the facet joints in the lumbar spine are the most predominant cause of back pain, resulting in facet joint syndrome (FJS). Conventional treatments for FJS are short-lived and have limitations and side effects. Thus, safer and more effective alternatives that can reduce pain and improve patient-reported outcomes are needed. Recently, the utilization of biologics, including the ones derived from perinatal tissue such as amniotic membrane (AM) and umbilical cord (UC), has significantly increased for regenerative medicine applications. This manuscript summarizes the outcomes of preclinical and clinical studies utilizing AM and/or UC for FJS. We identified no preclinical studies and 3 retrospective studies utilizing the search terms “amniotic membrane” and/or “umbilical cord” and “facet joint syndrome”. The administration of AM + UC is safe and potentially efficacious for patients with FJS. However, more preclinical studies and appropriately powered, multi-center, prospective non-randomized and randomized controlled studies with longer follow-up are warranted to further evaluate the efficacy of AM + UC to justify its clinical use. |
format | Online Article Text |
id | pubmed-10544465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105444652023-10-03 Amniotic membrane and/or umbilical cord tissue for treatment of facet joint syndrome: a narrative review Gupta, Ashim Maffulli, Nicola J Orthop Surg Res Review Musculoskeletal spine disorders, especially low back pain, induce enormous amounts of stress and financial burden on individuals and healthcare systems throughout the world. Disorders of the facet joints in the lumbar spine are the most predominant cause of back pain, resulting in facet joint syndrome (FJS). Conventional treatments for FJS are short-lived and have limitations and side effects. Thus, safer and more effective alternatives that can reduce pain and improve patient-reported outcomes are needed. Recently, the utilization of biologics, including the ones derived from perinatal tissue such as amniotic membrane (AM) and umbilical cord (UC), has significantly increased for regenerative medicine applications. This manuscript summarizes the outcomes of preclinical and clinical studies utilizing AM and/or UC for FJS. We identified no preclinical studies and 3 retrospective studies utilizing the search terms “amniotic membrane” and/or “umbilical cord” and “facet joint syndrome”. The administration of AM + UC is safe and potentially efficacious for patients with FJS. However, more preclinical studies and appropriately powered, multi-center, prospective non-randomized and randomized controlled studies with longer follow-up are warranted to further evaluate the efficacy of AM + UC to justify its clinical use. BioMed Central 2023-10-02 /pmc/articles/PMC10544465/ /pubmed/37784162 http://dx.doi.org/10.1186/s13018-023-04241-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Gupta, Ashim Maffulli, Nicola Amniotic membrane and/or umbilical cord tissue for treatment of facet joint syndrome: a narrative review |
title | Amniotic membrane and/or umbilical cord tissue for treatment of facet joint syndrome: a narrative review |
title_full | Amniotic membrane and/or umbilical cord tissue for treatment of facet joint syndrome: a narrative review |
title_fullStr | Amniotic membrane and/or umbilical cord tissue for treatment of facet joint syndrome: a narrative review |
title_full_unstemmed | Amniotic membrane and/or umbilical cord tissue for treatment of facet joint syndrome: a narrative review |
title_short | Amniotic membrane and/or umbilical cord tissue for treatment of facet joint syndrome: a narrative review |
title_sort | amniotic membrane and/or umbilical cord tissue for treatment of facet joint syndrome: a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544465/ https://www.ncbi.nlm.nih.gov/pubmed/37784162 http://dx.doi.org/10.1186/s13018-023-04241-2 |
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