Cargando…

Mild Prolongation of Prothrombin Time Does Not Affect the Safety and Prognosis of Transjugular Intrahepatic Portal Shunt: Based on Real-World Data

BACKGROUND/AIMS: The aim was to investigate the safety and prognosis of transjugular intrahepatic portal shunt in patients with mildly prolonged prothrombin time. MATERIALS AND METHODS: Two hundred fifty-three patients with portal hypertension who received transjugular intrahepatic portal shunt from...

Descripción completa

Detalles Bibliográficos
Autores principales: Bai, Yaowei, Liu, Jiacheng, Chen, Yang, Yang, Chongtu, Wang, Yingliang, Wang, Chaoyang, Ju, Shuguang, Zhou, Chen, Huang, Songjiang, Li, Tongqiang, Yao, Wei, Yao, Jinghong, Xiong, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Turkish Society of Gastroenterology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544647/
https://www.ncbi.nlm.nih.gov/pubmed/37458392
http://dx.doi.org/10.5152/tjg.2023.22410
_version_ 1785114544137306112
author Bai, Yaowei
Liu, Jiacheng
Chen, Yang
Yang, Chongtu
Wang, Yingliang
Wang, Chaoyang
Ju, Shuguang
Zhou, Chen
Huang, Songjiang
Li, Tongqiang
Yao, Wei
Yao, Jinghong
Xiong, Bin
author_facet Bai, Yaowei
Liu, Jiacheng
Chen, Yang
Yang, Chongtu
Wang, Yingliang
Wang, Chaoyang
Ju, Shuguang
Zhou, Chen
Huang, Songjiang
Li, Tongqiang
Yao, Wei
Yao, Jinghong
Xiong, Bin
author_sort Bai, Yaowei
collection PubMed
description BACKGROUND/AIMS: The aim was to investigate the safety and prognosis of transjugular intrahepatic portal shunt in patients with mildly prolonged prothrombin time. MATERIALS AND METHODS: Two hundred fifty-three patients with portal hypertension who received transjugular intrahepatic portal shunt from November 2015 to May 2021 in Wuhan Union Hospital were retrospectively selected. According to the preoperative prothrombin time, they were divided into 2 groups: 126 patients in the non-clinical significance group (prothrombin time prolongation <3 seconds) and 127 patients in the clinical significance group (3 seconds ≤ prothrombin time prolongation <6 seconds). A line chart of postoperative liver and kidney function was drawn, and Kaplan–Meier curve was used to analyze and compare the prognosis of the 2 groups. RESULTS: Transjugular intrahepatic portal shunt was successfully performed in all patients; the technical success rate was 100%, and no puncture-related complications occurred during perioperative period. The mean preoperative prothrombin time was 14.9 ± 0.7 seconds in the non-clinical significance group and 17.2 ± 0.8 seconds in the clinical significance group. During follow-up, 1-year stent dysfunction rates in the non-clinical significance group and clinical significance group were 3.5% and 6.9%, respectively, with no statistically significant difference (hazard ratio = 0.77, 95% CI = 0.30-1.93, log-rank P = .575). In addition, there were no significant differences in the cumulative survival rate (log rank P = .255), rebleeding rate (log-rank P = .392), and incidence of hepatic encephalopathy (log-rank P = .404) between the 2 groups. Subgroup analysis of the clinical significance group showed no significant difference in safety and prognosis between the 2 subgroups. CONCLUSION: Transjugular intrahepatic portal shunt is safe for portal hypertension patients with prothrombin time prolongation <6 seconds. There was no significant difference in prognosis between the non-clinical significance group and the clinical significance group.
format Online
Article
Text
id pubmed-10544647
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Turkish Society of Gastroenterology
record_format MEDLINE/PubMed
spelling pubmed-105446472023-10-03 Mild Prolongation of Prothrombin Time Does Not Affect the Safety and Prognosis of Transjugular Intrahepatic Portal Shunt: Based on Real-World Data Bai, Yaowei Liu, Jiacheng Chen, Yang Yang, Chongtu Wang, Yingliang Wang, Chaoyang Ju, Shuguang Zhou, Chen Huang, Songjiang Li, Tongqiang Yao, Wei Yao, Jinghong Xiong, Bin Turk J Gastroenterol Original Article BACKGROUND/AIMS: The aim was to investigate the safety and prognosis of transjugular intrahepatic portal shunt in patients with mildly prolonged prothrombin time. MATERIALS AND METHODS: Two hundred fifty-three patients with portal hypertension who received transjugular intrahepatic portal shunt from November 2015 to May 2021 in Wuhan Union Hospital were retrospectively selected. According to the preoperative prothrombin time, they were divided into 2 groups: 126 patients in the non-clinical significance group (prothrombin time prolongation <3 seconds) and 127 patients in the clinical significance group (3 seconds ≤ prothrombin time prolongation <6 seconds). A line chart of postoperative liver and kidney function was drawn, and Kaplan–Meier curve was used to analyze and compare the prognosis of the 2 groups. RESULTS: Transjugular intrahepatic portal shunt was successfully performed in all patients; the technical success rate was 100%, and no puncture-related complications occurred during perioperative period. The mean preoperative prothrombin time was 14.9 ± 0.7 seconds in the non-clinical significance group and 17.2 ± 0.8 seconds in the clinical significance group. During follow-up, 1-year stent dysfunction rates in the non-clinical significance group and clinical significance group were 3.5% and 6.9%, respectively, with no statistically significant difference (hazard ratio = 0.77, 95% CI = 0.30-1.93, log-rank P = .575). In addition, there were no significant differences in the cumulative survival rate (log rank P = .255), rebleeding rate (log-rank P = .392), and incidence of hepatic encephalopathy (log-rank P = .404) between the 2 groups. Subgroup analysis of the clinical significance group showed no significant difference in safety and prognosis between the 2 subgroups. CONCLUSION: Transjugular intrahepatic portal shunt is safe for portal hypertension patients with prothrombin time prolongation <6 seconds. There was no significant difference in prognosis between the non-clinical significance group and the clinical significance group. Turkish Society of Gastroenterology 2023-08-01 /pmc/articles/PMC10544647/ /pubmed/37458392 http://dx.doi.org/10.5152/tjg.2023.22410 Text en © 2023 authors https://creativecommons.org/licenses/by/4.0/ Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Original Article
Bai, Yaowei
Liu, Jiacheng
Chen, Yang
Yang, Chongtu
Wang, Yingliang
Wang, Chaoyang
Ju, Shuguang
Zhou, Chen
Huang, Songjiang
Li, Tongqiang
Yao, Wei
Yao, Jinghong
Xiong, Bin
Mild Prolongation of Prothrombin Time Does Not Affect the Safety and Prognosis of Transjugular Intrahepatic Portal Shunt: Based on Real-World Data
title Mild Prolongation of Prothrombin Time Does Not Affect the Safety and Prognosis of Transjugular Intrahepatic Portal Shunt: Based on Real-World Data
title_full Mild Prolongation of Prothrombin Time Does Not Affect the Safety and Prognosis of Transjugular Intrahepatic Portal Shunt: Based on Real-World Data
title_fullStr Mild Prolongation of Prothrombin Time Does Not Affect the Safety and Prognosis of Transjugular Intrahepatic Portal Shunt: Based on Real-World Data
title_full_unstemmed Mild Prolongation of Prothrombin Time Does Not Affect the Safety and Prognosis of Transjugular Intrahepatic Portal Shunt: Based on Real-World Data
title_short Mild Prolongation of Prothrombin Time Does Not Affect the Safety and Prognosis of Transjugular Intrahepatic Portal Shunt: Based on Real-World Data
title_sort mild prolongation of prothrombin time does not affect the safety and prognosis of transjugular intrahepatic portal shunt: based on real-world data
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544647/
https://www.ncbi.nlm.nih.gov/pubmed/37458392
http://dx.doi.org/10.5152/tjg.2023.22410
work_keys_str_mv AT baiyaowei mildprolongationofprothrombintimedoesnotaffectthesafetyandprognosisoftransjugularintrahepaticportalshuntbasedonrealworlddata
AT liujiacheng mildprolongationofprothrombintimedoesnotaffectthesafetyandprognosisoftransjugularintrahepaticportalshuntbasedonrealworlddata
AT chenyang mildprolongationofprothrombintimedoesnotaffectthesafetyandprognosisoftransjugularintrahepaticportalshuntbasedonrealworlddata
AT yangchongtu mildprolongationofprothrombintimedoesnotaffectthesafetyandprognosisoftransjugularintrahepaticportalshuntbasedonrealworlddata
AT wangyingliang mildprolongationofprothrombintimedoesnotaffectthesafetyandprognosisoftransjugularintrahepaticportalshuntbasedonrealworlddata
AT wangchaoyang mildprolongationofprothrombintimedoesnotaffectthesafetyandprognosisoftransjugularintrahepaticportalshuntbasedonrealworlddata
AT jushuguang mildprolongationofprothrombintimedoesnotaffectthesafetyandprognosisoftransjugularintrahepaticportalshuntbasedonrealworlddata
AT zhouchen mildprolongationofprothrombintimedoesnotaffectthesafetyandprognosisoftransjugularintrahepaticportalshuntbasedonrealworlddata
AT huangsongjiang mildprolongationofprothrombintimedoesnotaffectthesafetyandprognosisoftransjugularintrahepaticportalshuntbasedonrealworlddata
AT litongqiang mildprolongationofprothrombintimedoesnotaffectthesafetyandprognosisoftransjugularintrahepaticportalshuntbasedonrealworlddata
AT yaowei mildprolongationofprothrombintimedoesnotaffectthesafetyandprognosisoftransjugularintrahepaticportalshuntbasedonrealworlddata
AT yaojinghong mildprolongationofprothrombintimedoesnotaffectthesafetyandprognosisoftransjugularintrahepaticportalshuntbasedonrealworlddata
AT xiongbin mildprolongationofprothrombintimedoesnotaffectthesafetyandprognosisoftransjugularintrahepaticportalshuntbasedonrealworlddata