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Fulminant Hepatic Failure With Minimal Alcohol Consumption in a 25-Year-Old Female With Hereditary Hemochromatosis: A Rare Case

Hereditary hemochromatosis (HH) is an inherited disorder in which organ damage and other clinical manifestations are commonly seen in patients with a homozygous mutation involving C282Y of the HFE gene, causing increased iron absorption in the intestine. The liver is the primary site of iron deposit...

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Autores principales: Alvi, Ali Tariq, Santiago, Luis E, Nadeem, Zahid, Chaudhry, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544746/
https://www.ncbi.nlm.nih.gov/pubmed/37790043
http://dx.doi.org/10.7759/cureus.44544
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author Alvi, Ali Tariq
Santiago, Luis E
Nadeem, Zahid
Chaudhry, Ali
author_facet Alvi, Ali Tariq
Santiago, Luis E
Nadeem, Zahid
Chaudhry, Ali
author_sort Alvi, Ali Tariq
collection PubMed
description Hereditary hemochromatosis (HH) is an inherited disorder in which organ damage and other clinical manifestations are commonly seen in patients with a homozygous mutation involving C282Y of the HFE gene, causing increased iron absorption in the intestine. The liver is the primary site of iron deposition, and excessive iron overload can eventually lead to hepatic cirrhosis. Patients who drink significant amounts of alcohol are more likely to develop cirrhosis, and in females, it is commonly seen after menopause. We describe a young female with hereditary hemochromatosis who developed fulminant hepatic failure with minimal alcohol consumption at age 25.
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spelling pubmed-105447462023-10-03 Fulminant Hepatic Failure With Minimal Alcohol Consumption in a 25-Year-Old Female With Hereditary Hemochromatosis: A Rare Case Alvi, Ali Tariq Santiago, Luis E Nadeem, Zahid Chaudhry, Ali Cureus Internal Medicine Hereditary hemochromatosis (HH) is an inherited disorder in which organ damage and other clinical manifestations are commonly seen in patients with a homozygous mutation involving C282Y of the HFE gene, causing increased iron absorption in the intestine. The liver is the primary site of iron deposition, and excessive iron overload can eventually lead to hepatic cirrhosis. Patients who drink significant amounts of alcohol are more likely to develop cirrhosis, and in females, it is commonly seen after menopause. We describe a young female with hereditary hemochromatosis who developed fulminant hepatic failure with minimal alcohol consumption at age 25. Cureus 2023-09-01 /pmc/articles/PMC10544746/ /pubmed/37790043 http://dx.doi.org/10.7759/cureus.44544 Text en Copyright © 2023, Alvi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Alvi, Ali Tariq
Santiago, Luis E
Nadeem, Zahid
Chaudhry, Ali
Fulminant Hepatic Failure With Minimal Alcohol Consumption in a 25-Year-Old Female With Hereditary Hemochromatosis: A Rare Case
title Fulminant Hepatic Failure With Minimal Alcohol Consumption in a 25-Year-Old Female With Hereditary Hemochromatosis: A Rare Case
title_full Fulminant Hepatic Failure With Minimal Alcohol Consumption in a 25-Year-Old Female With Hereditary Hemochromatosis: A Rare Case
title_fullStr Fulminant Hepatic Failure With Minimal Alcohol Consumption in a 25-Year-Old Female With Hereditary Hemochromatosis: A Rare Case
title_full_unstemmed Fulminant Hepatic Failure With Minimal Alcohol Consumption in a 25-Year-Old Female With Hereditary Hemochromatosis: A Rare Case
title_short Fulminant Hepatic Failure With Minimal Alcohol Consumption in a 25-Year-Old Female With Hereditary Hemochromatosis: A Rare Case
title_sort fulminant hepatic failure with minimal alcohol consumption in a 25-year-old female with hereditary hemochromatosis: a rare case
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544746/
https://www.ncbi.nlm.nih.gov/pubmed/37790043
http://dx.doi.org/10.7759/cureus.44544
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