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Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression

Introduction: Although various therapies have been adopted to treat cancer, metastasis of tumor cells still is a big challenge that compromises therapeutic benefits. Methods: We herein report an injectable drug-loaded hybrid hydrogel that can achieve sonodynamic therapy (SDT) and chemodyanmic therap...

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Autores principales: Wang, Xiaoying, Zhu, Liyun, Zhou, Jianhui, Zhao, Lingzhou, Li, Jingchao, Liu, Changcun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544978/
https://www.ncbi.nlm.nih.gov/pubmed/37790250
http://dx.doi.org/10.3389/fbioe.2023.1281157
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author Wang, Xiaoying
Zhu, Liyun
Zhou, Jianhui
Zhao, Lingzhou
Li, Jingchao
Liu, Changcun
author_facet Wang, Xiaoying
Zhu, Liyun
Zhou, Jianhui
Zhao, Lingzhou
Li, Jingchao
Liu, Changcun
author_sort Wang, Xiaoying
collection PubMed
description Introduction: Although various therapies have been adopted to treat cancer, metastasis of tumor cells still is a big challenge that compromises therapeutic benefits. Methods: We herein report an injectable drug-loaded hybrid hydrogel that can achieve sonodynamic therapy (SDT) and chemodyanmic therapy (CDT) combined action and suppression of tumor metastasis. This alginate (ALG)-based hydrogel (termed as AMPS) contains manganese dioxide (MnO(2)) nanoparticles as the CDT agents, an organic polymer as the sonosensitizer, and a SIS3 drug as metastasis inhibitor. Results: AMPS is formed via the chelation of ALG by Ca(2+) in tumor microenvironment, in which MnO(2) nanoparticles mediate CDT via Fenton-like reaction and the organic polymers enable SDT under ultrasound (US) irradiation by generating singlet oxygen ((1)O(2)), allowing for combinational action of CDT and SDT. In addition, SIS3 is released from AMPS hydrogels to inhibit the metastasis of tumor cells. As such, the AMPS enables a combinational action of SDT and CDT to greatly inhibit the growths of subcutaneous tumors in living mice and also completely suppress the tumor metastasis in lungs and livers. Conclusion: This study thus offers a hybrid hydrogel platform for combinational therapy and metastasis suppression simultaneously.
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spelling pubmed-105449782023-10-03 Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression Wang, Xiaoying Zhu, Liyun Zhou, Jianhui Zhao, Lingzhou Li, Jingchao Liu, Changcun Front Bioeng Biotechnol Bioengineering and Biotechnology Introduction: Although various therapies have been adopted to treat cancer, metastasis of tumor cells still is a big challenge that compromises therapeutic benefits. Methods: We herein report an injectable drug-loaded hybrid hydrogel that can achieve sonodynamic therapy (SDT) and chemodyanmic therapy (CDT) combined action and suppression of tumor metastasis. This alginate (ALG)-based hydrogel (termed as AMPS) contains manganese dioxide (MnO(2)) nanoparticles as the CDT agents, an organic polymer as the sonosensitizer, and a SIS3 drug as metastasis inhibitor. Results: AMPS is formed via the chelation of ALG by Ca(2+) in tumor microenvironment, in which MnO(2) nanoparticles mediate CDT via Fenton-like reaction and the organic polymers enable SDT under ultrasound (US) irradiation by generating singlet oxygen ((1)O(2)), allowing for combinational action of CDT and SDT. In addition, SIS3 is released from AMPS hydrogels to inhibit the metastasis of tumor cells. As such, the AMPS enables a combinational action of SDT and CDT to greatly inhibit the growths of subcutaneous tumors in living mice and also completely suppress the tumor metastasis in lungs and livers. Conclusion: This study thus offers a hybrid hydrogel platform for combinational therapy and metastasis suppression simultaneously. Frontiers Media S.A. 2023-09-18 /pmc/articles/PMC10544978/ /pubmed/37790250 http://dx.doi.org/10.3389/fbioe.2023.1281157 Text en Copyright © 2023 Wang, Zhu, Zhou, Zhao, Li and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Wang, Xiaoying
Zhu, Liyun
Zhou, Jianhui
Zhao, Lingzhou
Li, Jingchao
Liu, Changcun
Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression
title Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression
title_full Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression
title_fullStr Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression
title_full_unstemmed Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression
title_short Drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression
title_sort drug-loaded hybrid hydrogels for sonodynamic-chemodyanmic therapy and tumor metastasis suppression
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544978/
https://www.ncbi.nlm.nih.gov/pubmed/37790250
http://dx.doi.org/10.3389/fbioe.2023.1281157
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