Function-structure approach reveals novel insights on the interplay of Immunoglobulin G 1 proteoforms and Fc gamma receptor IIa allotypes

Human Fc gamma receptor IIa (FcγRIIa) or CD32a has two major allotypes with a single amino acid difference at position 131 (histidine or arginine). Differences in FcγRIIa allotypes are known to impact immunological responses such as the clinical outcome of therapeutic monoclonal antibodies (mAbs). F...

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Detalles Bibliográficos
Autores principales: Lippold, Steffen, Mistry, Karishma, Lenka, Sunidhi, Whang, Kevin, Liu, Peilu, Pitschi, Sebastian, Kuhne, Felix, Reusch, Dietmar, Cadang, Lance, Knaupp, Alexander, Izadi, Saeed, Dunkle, Alexis, Yang, Feng, Schlothauer, Tilman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10544997/
https://www.ncbi.nlm.nih.gov/pubmed/37790943
http://dx.doi.org/10.3389/fimmu.2023.1260446

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