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Vertebral osteomyelitis as a hidden cause of persistent meningeal irritation in a patient with pneumococcal meningitis: A case report

RATIONALE: Pneumococcal meningitis generally develops from bacteremia and is often complicated by multiple organ infection. PATIENT CONCERNS: A 62-year-old man with no previous medical history developed progressive disturbance of consciousness preceded by high-grade fever and headache for a few days...

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Autores principales: Hamaguchi, Mai, Fujita, Hiroaki, Suzuki, Keisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545078/
https://www.ncbi.nlm.nih.gov/pubmed/33578609
http://dx.doi.org/10.1097/MD.0000000000024705
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author Hamaguchi, Mai
Fujita, Hiroaki
Suzuki, Keisuke
author_facet Hamaguchi, Mai
Fujita, Hiroaki
Suzuki, Keisuke
author_sort Hamaguchi, Mai
collection PubMed
description RATIONALE: Pneumococcal meningitis generally develops from bacteremia and is often complicated by multiple organ infection. PATIENT CONCERNS: A 62-year-old man with no previous medical history developed progressive disturbance of consciousness preceded by high-grade fever and headache for a few days. DIAGNOSIS: The patient was diagnosed with pneumococcal meningitis based on meningeal irritation, polymorphonuclear cell-predominant pleocytosis of the cerebrospinal fluid (CSF) and a positive pneumococcal urinary antigen test at a different hospital. Despite the administration of meropenem and vancomycin, his consciousness worsened, and the patient was transferred to our hospital. Marked nuchal stiffness was noted. The patient showed a disturbance of consciousness, with a Glasgow Coma Scale score of E3V2M5. No significant cranial nerve palsy, motor weakness or sensory impairment was observed. CSF examination showed polynuclear cell-predominant pleocytosis of 755/μL. Transthoracic echocardiography revealed infectious endocarditis. INTERVENTIONS: After the detection of penicillin-susceptible Streptococcus pneumoniae, the antibiotic regimen was changed to aminobenzylpenicillin 12 g/d and ceftriaxone 4 g/d, which improved the patient's consciousness and CSF findings. However, marked neck stiffness and neck pain persisted; we performed a systemic investigation that revealed cervical vertebral osteomyelitis and aortic aneurysm. OUTCOMES: After surgical treatment, the patient achieved complete remission of both conditions. LESSONS: We should consider vertebral osteomyelitis as a potential complication of meningitis when nuchal stiffness persists despite an improvement in meningitis.
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spelling pubmed-105450782023-10-03 Vertebral osteomyelitis as a hidden cause of persistent meningeal irritation in a patient with pneumococcal meningitis: A case report Hamaguchi, Mai Fujita, Hiroaki Suzuki, Keisuke Medicine (Baltimore) 5300 RATIONALE: Pneumococcal meningitis generally develops from bacteremia and is often complicated by multiple organ infection. PATIENT CONCERNS: A 62-year-old man with no previous medical history developed progressive disturbance of consciousness preceded by high-grade fever and headache for a few days. DIAGNOSIS: The patient was diagnosed with pneumococcal meningitis based on meningeal irritation, polymorphonuclear cell-predominant pleocytosis of the cerebrospinal fluid (CSF) and a positive pneumococcal urinary antigen test at a different hospital. Despite the administration of meropenem and vancomycin, his consciousness worsened, and the patient was transferred to our hospital. Marked nuchal stiffness was noted. The patient showed a disturbance of consciousness, with a Glasgow Coma Scale score of E3V2M5. No significant cranial nerve palsy, motor weakness or sensory impairment was observed. CSF examination showed polynuclear cell-predominant pleocytosis of 755/μL. Transthoracic echocardiography revealed infectious endocarditis. INTERVENTIONS: After the detection of penicillin-susceptible Streptococcus pneumoniae, the antibiotic regimen was changed to aminobenzylpenicillin 12 g/d and ceftriaxone 4 g/d, which improved the patient's consciousness and CSF findings. However, marked neck stiffness and neck pain persisted; we performed a systemic investigation that revealed cervical vertebral osteomyelitis and aortic aneurysm. OUTCOMES: After surgical treatment, the patient achieved complete remission of both conditions. LESSONS: We should consider vertebral osteomyelitis as a potential complication of meningitis when nuchal stiffness persists despite an improvement in meningitis. Lippincott Williams & Wilkins 2021-02-12 /pmc/articles/PMC10545078/ /pubmed/33578609 http://dx.doi.org/10.1097/MD.0000000000024705 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 5300
Hamaguchi, Mai
Fujita, Hiroaki
Suzuki, Keisuke
Vertebral osteomyelitis as a hidden cause of persistent meningeal irritation in a patient with pneumococcal meningitis: A case report
title Vertebral osteomyelitis as a hidden cause of persistent meningeal irritation in a patient with pneumococcal meningitis: A case report
title_full Vertebral osteomyelitis as a hidden cause of persistent meningeal irritation in a patient with pneumococcal meningitis: A case report
title_fullStr Vertebral osteomyelitis as a hidden cause of persistent meningeal irritation in a patient with pneumococcal meningitis: A case report
title_full_unstemmed Vertebral osteomyelitis as a hidden cause of persistent meningeal irritation in a patient with pneumococcal meningitis: A case report
title_short Vertebral osteomyelitis as a hidden cause of persistent meningeal irritation in a patient with pneumococcal meningitis: A case report
title_sort vertebral osteomyelitis as a hidden cause of persistent meningeal irritation in a patient with pneumococcal meningitis: a case report
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545078/
https://www.ncbi.nlm.nih.gov/pubmed/33578609
http://dx.doi.org/10.1097/MD.0000000000024705
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