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Linezolid-Induced Pancreatitis Associated with Lactic Acidosis and Relative Hypoglycemia: A Rare Case Report

BACKGROUND: Linezolid is known to cause side effects, including nausea, diarrhea, and headaches of short duration. As extended use of linezolid is becoming more common, additional rare side effects should be considered. CASE PRESENTATION: A 68-year-old man hospitalized for osteomyelitis developed se...

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Autores principales: Kim, Gi Eun, Ansari, Soubiya Mohammed Rizwan, Ali, Ateeque Mohamed, Adam, Ehab, Eltahir, Mugahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SMC Media Srl 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545144/
https://www.ncbi.nlm.nih.gov/pubmed/37789976
http://dx.doi.org/10.12890/2023_004041
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author Kim, Gi Eun
Ansari, Soubiya Mohammed Rizwan
Ali, Ateeque Mohamed
Adam, Ehab
Eltahir, Mugahid
author_facet Kim, Gi Eun
Ansari, Soubiya Mohammed Rizwan
Ali, Ateeque Mohamed
Adam, Ehab
Eltahir, Mugahid
author_sort Kim, Gi Eun
collection PubMed
description BACKGROUND: Linezolid is known to cause side effects, including nausea, diarrhea, and headaches of short duration. As extended use of linezolid is becoming more common, additional rare side effects should be considered. CASE PRESENTATION: A 68-year-old man hospitalized for osteomyelitis developed severe abdominal pain and altered mental status following five weeks of linezolid therapy. Laboratory studies showed very high lipase levels, lactic acidosis not responding to resuscitation, and relative hypoglycemia. All common causes of pancreatitis were ruled out, and a trial of linezolid withdrawal was done resulting in drastic improvement in the patient’s clinical status. CONCLUSIONS: For patients on extended course of linezolid who develop abdominal pain, drug-induced pancreatitis should be considered as a side effect, and a trial of withdrawal of linezolid should be undertaken. LEARNING POINTS: Linezolid can be associated with a rare but serious triad of adverse effects of pancreatitis, hypoglycemia, and lactic acidosis. Possible risk factors include a prolonged course of linezolid, renal dysfunction, and sepsis.
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spelling pubmed-105451442023-10-03 Linezolid-Induced Pancreatitis Associated with Lactic Acidosis and Relative Hypoglycemia: A Rare Case Report Kim, Gi Eun Ansari, Soubiya Mohammed Rizwan Ali, Ateeque Mohamed Adam, Ehab Eltahir, Mugahid Eur J Case Rep Intern Med Article BACKGROUND: Linezolid is known to cause side effects, including nausea, diarrhea, and headaches of short duration. As extended use of linezolid is becoming more common, additional rare side effects should be considered. CASE PRESENTATION: A 68-year-old man hospitalized for osteomyelitis developed severe abdominal pain and altered mental status following five weeks of linezolid therapy. Laboratory studies showed very high lipase levels, lactic acidosis not responding to resuscitation, and relative hypoglycemia. All common causes of pancreatitis were ruled out, and a trial of linezolid withdrawal was done resulting in drastic improvement in the patient’s clinical status. CONCLUSIONS: For patients on extended course of linezolid who develop abdominal pain, drug-induced pancreatitis should be considered as a side effect, and a trial of withdrawal of linezolid should be undertaken. LEARNING POINTS: Linezolid can be associated with a rare but serious triad of adverse effects of pancreatitis, hypoglycemia, and lactic acidosis. Possible risk factors include a prolonged course of linezolid, renal dysfunction, and sepsis. SMC Media Srl 2023-08-31 /pmc/articles/PMC10545144/ /pubmed/37789976 http://dx.doi.org/10.12890/2023_004041 Text en © EFIM 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This article is licensed under a Commons Attribution Non-Commercial 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Article
Kim, Gi Eun
Ansari, Soubiya Mohammed Rizwan
Ali, Ateeque Mohamed
Adam, Ehab
Eltahir, Mugahid
Linezolid-Induced Pancreatitis Associated with Lactic Acidosis and Relative Hypoglycemia: A Rare Case Report
title Linezolid-Induced Pancreatitis Associated with Lactic Acidosis and Relative Hypoglycemia: A Rare Case Report
title_full Linezolid-Induced Pancreatitis Associated with Lactic Acidosis and Relative Hypoglycemia: A Rare Case Report
title_fullStr Linezolid-Induced Pancreatitis Associated with Lactic Acidosis and Relative Hypoglycemia: A Rare Case Report
title_full_unstemmed Linezolid-Induced Pancreatitis Associated with Lactic Acidosis and Relative Hypoglycemia: A Rare Case Report
title_short Linezolid-Induced Pancreatitis Associated with Lactic Acidosis and Relative Hypoglycemia: A Rare Case Report
title_sort linezolid-induced pancreatitis associated with lactic acidosis and relative hypoglycemia: a rare case report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545144/
https://www.ncbi.nlm.nih.gov/pubmed/37789976
http://dx.doi.org/10.12890/2023_004041
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