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The association between short-term exposure to nitrogen dioxide and hospital admission for schizophrenia: A systematic review and meta-analysis

BACKGROUND: Ambient air pollution has been identified as a primary risk factor for mental disorders. In recent years, the relationship between exposure to ambient nitrogen dioxide (NO(2)) and the risk of hospital admissions (HAs) for schizophrenia has garnered increasing scientific interest, but evi...

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Autores principales: Xu, Jiating, Lan, Zhiyong, Xu, Penghao, Zhang, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545286/
https://www.ncbi.nlm.nih.gov/pubmed/37773873
http://dx.doi.org/10.1097/MD.0000000000035024
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author Xu, Jiating
Lan, Zhiyong
Xu, Penghao
Zhang, Zhihua
author_facet Xu, Jiating
Lan, Zhiyong
Xu, Penghao
Zhang, Zhihua
author_sort Xu, Jiating
collection PubMed
description BACKGROUND: Ambient air pollution has been identified as a primary risk factor for mental disorders. In recent years, the relationship between exposure to ambient nitrogen dioxide (NO(2)) and the risk of hospital admissions (HAs) for schizophrenia has garnered increasing scientific interest, but evidence from epidemiological studies has been inconsistent. Therefore, a systematic review and meta-analysis were conducted to comprehensively identify potential correlations. METHODS: A literature search in 3 international databases was conducted before December 31, 2022. Relative risk (RR) and corresponding 95% confidence intervals (CI) were calculated to evaluate the strength of the associations. Summary effect sizes were calculated using a random-effects model due to the expected heterogeneity (I(2) over 50%). RESULTS: A total of ten eligible studies were included in the meta-analysis, including 1,412,860 participants. The pooled analysis found that an increased risk of HAs for schizophrenia was associated with exposure to each increase of 10 μg/m(3) in NO(2) (RR = 1.029, 95% CI = 1.016–1.041, P < .001). However, the heterogeneity was high for the summary estimates, reducing the credibility of the evidence. In 2-pollutant models, results for NO(2) increased by 0.3%, 0.2% and 2.3%, respectively, after adjusting for PM(2.5), PM(10) and SO(2). CONCLUSIONS: This study provides evidence that NO(2) exposure significantly increases the risk of hospital admission for schizophrenia. Future studies are required to clarify the potential biological mechanism between schizophrenia and NO(2) exposure to provide a more definitive result.
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spelling pubmed-105452862023-10-03 The association between short-term exposure to nitrogen dioxide and hospital admission for schizophrenia: A systematic review and meta-analysis Xu, Jiating Lan, Zhiyong Xu, Penghao Zhang, Zhihua Medicine (Baltimore) 5000 BACKGROUND: Ambient air pollution has been identified as a primary risk factor for mental disorders. In recent years, the relationship between exposure to ambient nitrogen dioxide (NO(2)) and the risk of hospital admissions (HAs) for schizophrenia has garnered increasing scientific interest, but evidence from epidemiological studies has been inconsistent. Therefore, a systematic review and meta-analysis were conducted to comprehensively identify potential correlations. METHODS: A literature search in 3 international databases was conducted before December 31, 2022. Relative risk (RR) and corresponding 95% confidence intervals (CI) were calculated to evaluate the strength of the associations. Summary effect sizes were calculated using a random-effects model due to the expected heterogeneity (I(2) over 50%). RESULTS: A total of ten eligible studies were included in the meta-analysis, including 1,412,860 participants. The pooled analysis found that an increased risk of HAs for schizophrenia was associated with exposure to each increase of 10 μg/m(3) in NO(2) (RR = 1.029, 95% CI = 1.016–1.041, P < .001). However, the heterogeneity was high for the summary estimates, reducing the credibility of the evidence. In 2-pollutant models, results for NO(2) increased by 0.3%, 0.2% and 2.3%, respectively, after adjusting for PM(2.5), PM(10) and SO(2). CONCLUSIONS: This study provides evidence that NO(2) exposure significantly increases the risk of hospital admission for schizophrenia. Future studies are required to clarify the potential biological mechanism between schizophrenia and NO(2) exposure to provide a more definitive result. Lippincott Williams & Wilkins 2023-09-29 /pmc/articles/PMC10545286/ /pubmed/37773873 http://dx.doi.org/10.1097/MD.0000000000035024 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5000
Xu, Jiating
Lan, Zhiyong
Xu, Penghao
Zhang, Zhihua
The association between short-term exposure to nitrogen dioxide and hospital admission for schizophrenia: A systematic review and meta-analysis
title The association between short-term exposure to nitrogen dioxide and hospital admission for schizophrenia: A systematic review and meta-analysis
title_full The association between short-term exposure to nitrogen dioxide and hospital admission for schizophrenia: A systematic review and meta-analysis
title_fullStr The association between short-term exposure to nitrogen dioxide and hospital admission for schizophrenia: A systematic review and meta-analysis
title_full_unstemmed The association between short-term exposure to nitrogen dioxide and hospital admission for schizophrenia: A systematic review and meta-analysis
title_short The association between short-term exposure to nitrogen dioxide and hospital admission for schizophrenia: A systematic review and meta-analysis
title_sort association between short-term exposure to nitrogen dioxide and hospital admission for schizophrenia: a systematic review and meta-analysis
topic 5000
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545286/
https://www.ncbi.nlm.nih.gov/pubmed/37773873
http://dx.doi.org/10.1097/MD.0000000000035024
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