Comparative motor effectiveness of non-invasive brain stimulation techniques in patients with Parkinson’s disease: A network meta-analysis

BACKGROUND: Although noninvasive brain stimulation (NIBS) techniques are an effective alternative treatment option, their relative effects in patients with Parkinson’s disease (PD) remain undefined. Here, we aimed to compare motor efficacy of the NIBS techniques in PD. METHODS: We carried out an electronic search in PubMed, Embase, Cochrane Library, CINAHL, PEDro and PsycINFO (accessed via Ovid) for articles published until August 2022. The treatment efficacy of motor function was quantified by the Unified Parkinson’s disease rating scale part III. RESULTS: 28 randomized controlled trials with parallel group were included in the analysis, enrolling 1057 patients. In the “on” state, high-frequency repetitive transcranial magnetic stimulation (HFrTMS) conferred better short-term and long-term efficacy compared to transcranial direct current stimulation. Surface under the cumulative ranking curve rank showed that HFrTMS combined with transcranial direct current stimulation and low-frequency TMS ranked first among PD in improving motor function. In the “off” state, there were no significant differences in most of the treatments, but surface under the cumulative ranking curve rank showed that continuous theta burst stimulation and low-frequency TMS had the highest short- and long-term effect in improving motor function. CONCLUSION: HFrTMS is an effective intervention in improving motor function. Besides, its combination with another NIBS technique produces better therapeutic effects in the “on” state.