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Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model

The APOE4 genotype is the strongest risk factor for the pathogenesis of sporadic Alzheimer’s disease (AD), but the detailed molecular mechanism of APOE4-mediated synaptic impairment remains to be determined. In this study, we generated a human astrocyte model carrying the APOE3 or APOE4 genotype usi...

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Detalles Bibliográficos
Autores principales:	Watanabe, Hirotaka, Murakami, Rei, Tsumagari, Kazuya, Morimoto, Satoru, Hashimoto, Tadafumi, Imaizumi, Kent, Sonn, Iki, Yamada, Kaoru, Saito, Yuko, Murayama, Shigeo, Iwatsubo, Takeshi, Okano, Hideyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545487/ https://www.ncbi.nlm.nih.gov/pubmed/37657448 http://dx.doi.org/10.1016/j.stemcr.2023.08.002

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