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C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes

Transmembrane protein 106B (TMEM106B) is a tightly regulated glycoprotein predominantly localized to endosomes and lysosomes. Genetic studies have implicated TMEM106B haplotypes in the development of multiple neurodegenerative diseases with the strongest effect in frontotemporal lobar degeneration w...

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Detalles Bibliográficos
Autores principales:	T. Vicente, Cristina, Perneel, Jolien, Wynants, Sarah, Heeman, Bavo, Van den Broeck, Marleen, Baker, Matt, Cheung, Simon, Faura, Júlia, Mackenzie, Ian R A, Rademakers, Rosa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545506/ https://www.ncbi.nlm.nih.gov/pubmed/37100087 http://dx.doi.org/10.1093/brain/awad133

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