Abl kinase-mediated FUS Tyr526 phosphorylation alters nucleocytoplasmic FUS localization in FTLD-FUS

Nuclear to cytoplasmic mislocalization and aggregation of multiple RNA-binding proteins (RBPs), including FUS, are the main neuropathological features of the majority of cases of amyotrophic lateral sclerosis (ALS) and frontotemporal lobular degeneration (FTLD). In ALS-FUS, these aggregates arise fr...

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Detalles Bibliográficos
Autores principales: Motaln, Helena, Čerček, Urša, Yamoah, Alfred, Tripathi, Priyanka, Aronica, Eleonora, Goswami, Anand, Rogelj, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545532/
https://www.ncbi.nlm.nih.gov/pubmed/37071594
http://dx.doi.org/10.1093/brain/awad130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545532/
https://www.ncbi.nlm.nih.gov/pubmed/37071594
http://dx.doi.org/10.1093/brain/awad130

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