A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model

Multiple sclerosis (MS) involves the infiltration of autoreactive T cells into the CNS, yet we lack a comprehensive understanding of the signaling pathways that regulate this process. Here, we conducted a genome-wide in vivo CRISPR screen in a rat MS model and identified 5 essential brakes and 18 es...

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Detalles Bibliográficos
Autores principales: Kendirli, Arek, de la Rosa, Clara, Lämmle, Katrin F., Eglseer, Klara, Bauer, Isabel J., Kavaka, Vladyslav, Winklmeier, Stephan, Zhuo, La, Wichmann, Christian, Gerdes, Lisa Ann, Kümpfel, Tania, Dornmair, Klaus, Beltrán, Eduardo, Kerschensteiner, Martin, Kawakami, Naoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545543/
https://www.ncbi.nlm.nih.gov/pubmed/37709997
http://dx.doi.org/10.1038/s41593-023-01432-2

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