Stromal Interaction Molecule 1 Maintains β-Cell Identity and Function in Female Mice Through Preservation of G-Protein–Coupled Estrogen Receptor 1 Signaling

Altered endoplasmic reticulum (ER) Ca(2+) signaling has been linked with β-cell dysfunction and diabetes development. Store-operated Ca(2+) entry replenishes ER Ca(2+) through reversible gating of plasma membrane Ca(2+) channels by the ER Ca(2+) sensor, stromal interaction molecule 1 (STIM1). For ch...

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Detalles Bibliográficos
Autores principales: Sohn, Paul, McLaughlin, Madeline R., Krishnan, Preethi, Wu, Wenting, Slak Rupnik, Marjan, Takasu, Akira, Senda, Toshiya, Lee, Chih-Chun, Kono, Tatsuyoshi, Evans-Molina, Carmella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2023
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545557/
https://www.ncbi.nlm.nih.gov/pubmed/37478155
http://dx.doi.org/10.2337/db22-0988

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