Cargando…

Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells

Whole-body glucose homeostasis is coordinated through secretion of glucagon and insulin from pancreatic islets. When glucose is low, glucagon is released from α-cells to stimulate hepatic glucose production. However, the mechanisms that regulate glucagon secretion from pancreatic α-cells remain uncl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Armour, Sarah L., Frueh, Alexander, Chibalina, Margarita V., Dou, Haiqiang, Argemi-Muntadas, Lidia, Hamilton, Alexander, Katzilieris-Petras, Georgios, Carmeliet, Peter, Davies, Benjamin, Moritz, Thomas, Eliasson, Lena, Rorsman, Patrik, Knudsen, Jakob G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2023
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545563/ https://www.ncbi.nlm.nih.gov/pubmed/37494670 http://dx.doi.org/10.2337/db23-0056

Ejemplares similares

CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets
por: Briant, Linford J.B., et al.
Publicado: (2018)

Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in α-Cells Inhibits Glucagon Secretion From Human Islets
por: Ramracheya, Reshma, et al.
Publicado: (2010)

Sodium, Glucose and Dysregulated Glucagon Secretion: The Potential of Sodium Glucose Transporters
por: Armour, Sarah L., et al.
Publicado: (2022)

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production
por: Knudsen, Jakob G., et al.
Publicado: (2019)

‘Resistance is futile?’ – paradoxical inhibitory effects of K(ATP) channel closure in glucagon‐secreting α‐cells
por: Zhang, Quan, et al.
Publicado: (2020)

Glucagon Acting at the GLP-1 Receptor Contributes to β-Cell Regeneration Induced by Glucagon Receptor Antagonism in Diabetic Mice
por: Wei, Tianjiao, et al.
Publicado: (2023)

γ-Aminobutyric Acid (GABA) Is an Autocrine Excitatory Transmitter in Human Pancreatic β-Cells
por: Braun, Matthias, et al.
Publicado: (2010)

Glucagon Resistance and Decreased Susceptibility to Diabetes in a Model of Chronic Hyperglucagonemia
por: Bozadjieva Kramer, Nadejda, et al.
Publicado: (2021)

Mitochondrial GTP Insensitivity Contributes to Hypoglycemia in Hyperinsulinemia Hyperammonemia by Inhibiting Glucagon Release
por: Kibbey, Richard G., et al.
Publicado: (2014)

Glucagon Receptor Antagonist–Stimulated α-Cell Proliferation Is Severely Restricted With Advanced Age
por: Lam, Carol J., et al.
Publicado: (2019)

Reduced Insulin Exocytosis in Human Pancreatic β-Cells With Gene Variants Linked to Type 2 Diabetes
por: Rosengren, Anders H., et al.
Publicado: (2012)

GLP‐1 suppresses glucagon secretion in human pancreatic alpha‐cells by inhibition of P/Q‐type Ca(2+) channels
por: Ramracheya, Reshma, et al.
Publicado: (2018)

Combination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic NOD Mice
por: Suarez-Pinzon, Wilma L., et al.
Publicado: (2008)

EphA4 Receptor Forward Signaling Inhibits Glucagon Secretion From α-Cells
por: Hutchens, Troy, et al.
Publicado: (2015)

Gastric Bypass Surgery Enhances Glucagon-Like Peptide 1–Stimulated Postprandial Insulin Secretion in Humans
por: Salehi, Marzieh, et al.
Publicado: (2011)

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
por: Vergari, Elisa, et al.
Publicado: (2019)

Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice
por: Thorel, Fabrizio, et al.
Publicado: (2011)

Glucagon-Like Peptide 1 Inhibits the Sirtuin Deacetylase SirT1 to Stimulate Pancreatic β-Cell Mass Expansion
por: Bastien-Dionne, Pierre-Olivier, et al.
Publicado: (2011)

In Situ Electrophysiological Examination of Pancreatic α Cells in the Streptozotocin-Induced Diabetes Model, Revealing the Cellular Basis of Glucagon Hypersecretion
por: Huang, Ya-Chi, et al.
Publicado: (2013)

Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist Stimulates Insulin Secretion in Rodents and From Human Islets
por: Sloop, Kyle W., et al.
Publicado: (2010)

Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet
por: Kellard, Joely A., et al.
Publicado: (2020)

Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells
por: Nagao, Mototsugu, et al.
Publicado: (2020)

Biphasic voltage‐dependent inactivation of human Na(V)1.3, 1.6 and 1.7 Na(+) channels expressed in rodent insulin‐secreting cells
por: Godazgar, Mahdieh, et al.
Publicado: (2018)

A Variation on the Theme: SGLT2 Inhibition and Glucagon Secretion in Human Islets
por: Hodson, David J., et al.
Publicado: (2020)

Glucagon secretion from pancreatic α-cells
por: Briant, Linford, et al.
Publicado: (2016)

The human batokine EPDR1 regulates β-cell metabolism and function
por: Cataldo, Luis Rodrigo, et al.
Publicado: (2022)

A K(ATP) Channel-Dependent Pathway within α Cells Regulates Glucagon Release from Both Rodent and Human Islets of Langerhans
por: MacDonald, Patrick E, et al.
Publicado: (2007)

Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon
por: Collins, S. C., et al.
Publicado: (2008)

Decreased Fetal Size Is Associated With β-Cell Hyperfunction in Early Life and Failure With Age
por: Chakravarthy, Manu V., et al.
Publicado: (2008)

miR-375 Targets 3′-Phosphoinositide–Dependent Protein Kinase-1 and Regulates Glucose-Induced Biological Responses in Pancreatic β-Cells
por: El Ouaamari, Abdelfattah, et al.
Publicado: (2008)

Postnatal Expansion of the Pancreatic β-Cell Mass Is Dependent on Survivin
por: Jiang, Yuying, et al.
Publicado: (2008)

Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction
por: Lovis, Pascal, et al.
Publicado: (2008)

Spontaneous Diabetes in Hemizygous Human Amylin Transgenic Mice That Developed Neither Islet Amyloid nor Peripheral Insulin Resistance
por: Wong, Winifred P.S., et al.
Publicado: (2008)

Hepatocyte Growth Factor Enhances Engraftment and Function of Nonhuman Primate Islets
por: Fiaschi-Taesch, Nathalie M., et al.
Publicado: (2008)

Mouse Pancreatic Endocrine Cell Transcriptome Defined in the Embryonic Ngn3-Null Mouse
por: Juhl, Kirstine, et al.
Publicado: (2008)

Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling
por: Åkerfeldt, Mia C., et al.
Publicado: (2008)

Small Interfering RNA–Mediated Suppression of Proislet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets in Culture
por: Marzban, Lucy, et al.
Publicado: (2008)

Lessons From the First Comprehensive Molecular Characterization of Cell Cycle Control in Rodent Insulinoma Cell Lines
por: Cozar-Castellano, Irene, et al.
Publicado: (2008)

β-Cell Proliferation, but Not Neogenesis, Following 60% Partial Pancreatectomy Is Impaired in the Absence of FoxM1
por: Ackermann Misfeldt, Amanda, et al.
Publicado: (2008)

MAPK Kinase Kinase-1 Is Essential for Cytokine-Induced c-Jun NH(2)-Terminal Kinase and Nuclear Factor-κB Activation in Human Pancreatic Islet Cells
por: Mokhtari, Dariush, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_iemo36bar0e1bu8oso9idjip9g