Lactobacillus-derived extracellular vesicles counteract Aβ42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice

Mounting evidence suggests that probiotics are beneficial for treating Alzheimer’s disease (AD). However, the mechanisms by which specific probiotics modify AD pathophysiology are not clearly understood. In this study, we investigated whether Lactobacillus paracasei-derived extracellular vesicles (L...

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Detalles Bibliográficos
Autores principales: Kwon, Hyejin, Lee, Eun-Hwa, Park, So-Young, Park, Jin-Young, Hong, Jin-Hwan, Kim, Eun-Kyung, Shin, Tae-Seop, Kim, Yoon-Keun, Han, Pyung-Lim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545704/
https://www.ncbi.nlm.nih.gov/pubmed/37704750
http://dx.doi.org/10.1038/s12276-023-01084-z

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