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CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system

The cluster of differentiation 1 (CD1) molecule differs from major histocompatibility complex class I and II because it presents glycolipid/lipid antigens. Moreover, the CD1-restricted T cells that recognize these self and foreign antigens participate in both innate and adaptive immune responses. CD...

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Autores principales: Kim, Seohyun, Cho, Sumin, Kim, Ji Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545705/
https://www.ncbi.nlm.nih.gov/pubmed/37696897
http://dx.doi.org/10.1038/s12276-023-01053-6
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author Kim, Seohyun
Cho, Sumin
Kim, Ji Hyung
author_facet Kim, Seohyun
Cho, Sumin
Kim, Ji Hyung
author_sort Kim, Seohyun
collection PubMed
description The cluster of differentiation 1 (CD1) molecule differs from major histocompatibility complex class I and II because it presents glycolipid/lipid antigens. Moreover, the CD1-restricted T cells that recognize these self and foreign antigens participate in both innate and adaptive immune responses. CD1s are constitutively expressed by professional and nonprofessional antigen-presenting cells in mucosal tissues, namely, the skin, lung, and intestine. This suggests that CD1-reactive T cells are involved in the immune responses of these tissues. Indeed, evidence suggests that these cells play important roles in diverse diseases, such as inflammation, autoimmune disease, and infection. Recent studies elucidating the molecular mechanisms by which CD1 presents lipid antigens suggest that defects in these mechanisms could contribute to the activities of CD1-reactive T cells. Thus, improving our understanding of these mechanisms could lead to new and effective therapeutic approaches to CD1-associated diseases. In this review, we discuss the CD1-mediated antigen presentation system and its roles in mucosal tissue immunity.
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spelling pubmed-105457052023-10-04 CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system Kim, Seohyun Cho, Sumin Kim, Ji Hyung Exp Mol Med Review Article The cluster of differentiation 1 (CD1) molecule differs from major histocompatibility complex class I and II because it presents glycolipid/lipid antigens. Moreover, the CD1-restricted T cells that recognize these self and foreign antigens participate in both innate and adaptive immune responses. CD1s are constitutively expressed by professional and nonprofessional antigen-presenting cells in mucosal tissues, namely, the skin, lung, and intestine. This suggests that CD1-reactive T cells are involved in the immune responses of these tissues. Indeed, evidence suggests that these cells play important roles in diverse diseases, such as inflammation, autoimmune disease, and infection. Recent studies elucidating the molecular mechanisms by which CD1 presents lipid antigens suggest that defects in these mechanisms could contribute to the activities of CD1-reactive T cells. Thus, improving our understanding of these mechanisms could lead to new and effective therapeutic approaches to CD1-associated diseases. In this review, we discuss the CD1-mediated antigen presentation system and its roles in mucosal tissue immunity. Nature Publishing Group UK 2023-09-11 /pmc/articles/PMC10545705/ /pubmed/37696897 http://dx.doi.org/10.1038/s12276-023-01053-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Kim, Seohyun
Cho, Sumin
Kim, Ji Hyung
CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system
title CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system
title_full CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system
title_fullStr CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system
title_full_unstemmed CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system
title_short CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system
title_sort cd1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545705/
https://www.ncbi.nlm.nih.gov/pubmed/37696897
http://dx.doi.org/10.1038/s12276-023-01053-6
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