adgrl3.1-deficient zebrafish show noradrenaline-mediated externalizing behaviors, and altered expression of externalizing disorder-candidate genes, suggesting functional targets for treatment

Externalizing disorders (ED) are a cause of concern for public health, and their high heritability makes genetic risk factors a priority for research. Adhesion G-Protein-Coupled Receptor L3 (ADGRL3) is strongly linked to several EDs, and loss-of-function models have shown the impacts of this gene on...

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Detalles Bibliográficos
Autores principales: Fontana, Barbara D., Reichmann, Florian, Tilley, Ceinwen A., Lavlou, Perrine, Shkumatava, Alena, Alnassar, Nancy, Hillman, Courtney, Karlsson, Karl Ægir, Norton, William H. J., Parker, Matthew O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545713/
https://www.ncbi.nlm.nih.gov/pubmed/37783687
http://dx.doi.org/10.1038/s41398-023-02601-4

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