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Double-edged sword: γδ T cells in mucosal homeostasis and disease

The mucosa is a tissue that covers numerous body surfaces, including the respiratory tract, digestive tract, eye, and urogenital tract. Mucosa is in direct contact with pathogens, and γδ T cells perform various roles in the tissue. γδ T cells efficiently defend the mucosa from various pathogens, suc...

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Autores principales: Kang, In, Kim, Yumin, Lee, Heung Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545763/
https://www.ncbi.nlm.nih.gov/pubmed/37696894
http://dx.doi.org/10.1038/s12276-023-00985-3
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author Kang, In
Kim, Yumin
Lee, Heung Kyu
author_facet Kang, In
Kim, Yumin
Lee, Heung Kyu
author_sort Kang, In
collection PubMed
description The mucosa is a tissue that covers numerous body surfaces, including the respiratory tract, digestive tract, eye, and urogenital tract. Mucosa is in direct contact with pathogens, and γδ T cells perform various roles in the tissue. γδ T cells efficiently defend the mucosa from various pathogens, such as viruses, bacteria, and fungi. In addition, γδ T cells are necessary for the maintenance of homeostasis because they select specific organisms in the microbiota and perform immunoregulatory functions. Furthermore, γδ T cells directly facilitate pregnancy by producing growth factors. However, γδ T cells can also play detrimental roles in mucosal health by amplifying inflammation, thereby worsening allergic responses. Moreover, these cells can act as major players in autoimmune diseases. Despite their robust roles in the mucosa, the application of γδ T cells in clinical practice is lacking because of factors such as gaps between mice and human cells, insufficient knowledge of the target of γδ T cells, and the small population of γδ T cells. However, γδ T cells may be attractive targets for clinical use due to their effector functions and low risk of inducing graft-versus-host disease. Therefore, robust research on γδ T cells is required to understand the crucial features of these cells and apply these knowledges to clinical practices.
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spelling pubmed-105457632023-10-04 Double-edged sword: γδ T cells in mucosal homeostasis and disease Kang, In Kim, Yumin Lee, Heung Kyu Exp Mol Med Review Article The mucosa is a tissue that covers numerous body surfaces, including the respiratory tract, digestive tract, eye, and urogenital tract. Mucosa is in direct contact with pathogens, and γδ T cells perform various roles in the tissue. γδ T cells efficiently defend the mucosa from various pathogens, such as viruses, bacteria, and fungi. In addition, γδ T cells are necessary for the maintenance of homeostasis because they select specific organisms in the microbiota and perform immunoregulatory functions. Furthermore, γδ T cells directly facilitate pregnancy by producing growth factors. However, γδ T cells can also play detrimental roles in mucosal health by amplifying inflammation, thereby worsening allergic responses. Moreover, these cells can act as major players in autoimmune diseases. Despite their robust roles in the mucosa, the application of γδ T cells in clinical practice is lacking because of factors such as gaps between mice and human cells, insufficient knowledge of the target of γδ T cells, and the small population of γδ T cells. However, γδ T cells may be attractive targets for clinical use due to their effector functions and low risk of inducing graft-versus-host disease. Therefore, robust research on γδ T cells is required to understand the crucial features of these cells and apply these knowledges to clinical practices. Nature Publishing Group UK 2023-09-11 /pmc/articles/PMC10545763/ /pubmed/37696894 http://dx.doi.org/10.1038/s12276-023-00985-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Kang, In
Kim, Yumin
Lee, Heung Kyu
Double-edged sword: γδ T cells in mucosal homeostasis and disease
title Double-edged sword: γδ T cells in mucosal homeostasis and disease
title_full Double-edged sword: γδ T cells in mucosal homeostasis and disease
title_fullStr Double-edged sword: γδ T cells in mucosal homeostasis and disease
title_full_unstemmed Double-edged sword: γδ T cells in mucosal homeostasis and disease
title_short Double-edged sword: γδ T cells in mucosal homeostasis and disease
title_sort double-edged sword: γδ t cells in mucosal homeostasis and disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545763/
https://www.ncbi.nlm.nih.gov/pubmed/37696894
http://dx.doi.org/10.1038/s12276-023-00985-3
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