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Hypersensitive MR angiography based on interlocking stratagem for diagnosis of cardiac-cerebral vascular diseases
Magnetic resonance (MR) angiography is one of the main diagnostic approaches for cardiac-cerebral vascular diseases. Nevertheless, the non-contrast-enhanced MR angiography suffers from its intrinsic problems derived from the blood flow-dependency, while the clinical Gd-chelating contrast agents are...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545789/ https://www.ncbi.nlm.nih.gov/pubmed/37783733 http://dx.doi.org/10.1038/s41467-023-41783-9 |
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author | Zhang, Peisen Cheng, Junwei Lu, Yijie Zhang, Ni Wu, Xiaoai Lin, Hua Li, Wei Wang, Jian Winnik, Mitchell A. Gan, Zhihua Hou, Yi |
author_facet | Zhang, Peisen Cheng, Junwei Lu, Yijie Zhang, Ni Wu, Xiaoai Lin, Hua Li, Wei Wang, Jian Winnik, Mitchell A. Gan, Zhihua Hou, Yi |
author_sort | Zhang, Peisen |
collection | PubMed |
description | Magnetic resonance (MR) angiography is one of the main diagnostic approaches for cardiac-cerebral vascular diseases. Nevertheless, the non-contrast-enhanced MR angiography suffers from its intrinsic problems derived from the blood flow-dependency, while the clinical Gd-chelating contrast agents are limited by their rapid vascular extravasation. Herein, we report a hypersensitive MR angiography strategy based on interlocking stratagem of zwitterionic Gd-chelate contrast agents (PAA-Gd). The longitudinal molar relaxivity of PAA-Gd was 4.6-times higher than that of individual Gd-chelates as well as appropriate blood half-life (73.8 min) and low immunogenicity, enabling sophisticated micro-vessels angiography with a resolution at the order of hundred micrometers. A series of animal models of cardiac-cerebrovascular diseases have been built for imaging studies on a 7.0 T MRI scanner, while the clinical translation potential of PAA-Gd has been evaluated on swine on a 3.0 T clinical MRI scanner. The current studies offer a promising strategy for precise diagnosis of vascular diseases. |
format | Online Article Text |
id | pubmed-10545789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-105457892023-10-04 Hypersensitive MR angiography based on interlocking stratagem for diagnosis of cardiac-cerebral vascular diseases Zhang, Peisen Cheng, Junwei Lu, Yijie Zhang, Ni Wu, Xiaoai Lin, Hua Li, Wei Wang, Jian Winnik, Mitchell A. Gan, Zhihua Hou, Yi Nat Commun Article Magnetic resonance (MR) angiography is one of the main diagnostic approaches for cardiac-cerebral vascular diseases. Nevertheless, the non-contrast-enhanced MR angiography suffers from its intrinsic problems derived from the blood flow-dependency, while the clinical Gd-chelating contrast agents are limited by their rapid vascular extravasation. Herein, we report a hypersensitive MR angiography strategy based on interlocking stratagem of zwitterionic Gd-chelate contrast agents (PAA-Gd). The longitudinal molar relaxivity of PAA-Gd was 4.6-times higher than that of individual Gd-chelates as well as appropriate blood half-life (73.8 min) and low immunogenicity, enabling sophisticated micro-vessels angiography with a resolution at the order of hundred micrometers. A series of animal models of cardiac-cerebrovascular diseases have been built for imaging studies on a 7.0 T MRI scanner, while the clinical translation potential of PAA-Gd has been evaluated on swine on a 3.0 T clinical MRI scanner. The current studies offer a promising strategy for precise diagnosis of vascular diseases. Nature Publishing Group UK 2023-10-02 /pmc/articles/PMC10545789/ /pubmed/37783733 http://dx.doi.org/10.1038/s41467-023-41783-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zhang, Peisen Cheng, Junwei Lu, Yijie Zhang, Ni Wu, Xiaoai Lin, Hua Li, Wei Wang, Jian Winnik, Mitchell A. Gan, Zhihua Hou, Yi Hypersensitive MR angiography based on interlocking stratagem for diagnosis of cardiac-cerebral vascular diseases |
title | Hypersensitive MR angiography based on interlocking stratagem for diagnosis of cardiac-cerebral vascular diseases |
title_full | Hypersensitive MR angiography based on interlocking stratagem for diagnosis of cardiac-cerebral vascular diseases |
title_fullStr | Hypersensitive MR angiography based on interlocking stratagem for diagnosis of cardiac-cerebral vascular diseases |
title_full_unstemmed | Hypersensitive MR angiography based on interlocking stratagem for diagnosis of cardiac-cerebral vascular diseases |
title_short | Hypersensitive MR angiography based on interlocking stratagem for diagnosis of cardiac-cerebral vascular diseases |
title_sort | hypersensitive mr angiography based on interlocking stratagem for diagnosis of cardiac-cerebral vascular diseases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545789/ https://www.ncbi.nlm.nih.gov/pubmed/37783733 http://dx.doi.org/10.1038/s41467-023-41783-9 |
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