PIWI-interacting RNA expression regulates pathogenesis in a Caenorhabditis elegans model of Lewy body disease

PIWI-interacting RNAs (piRNAs) are small noncoding RNAs that regulate gene expression, yet their molecular functions in neurobiology are unclear. While investigating neurodegeneration mechanisms using human α-syn(A53T)(Tg) and Aβ(Tg);α-syn(A53T)(Tg) pan-neuronal overexpressing strains, we unexpected...

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Detalles Bibliográficos
Autores principales: Huang, Xiaobing, Wang, Changliang, Zhang, Tianjiao, Li, Rongzhen, Chen, Liang, Leung, Ka Lai, Lakso, Merja, Zhou, Qinghua, Zhang, Hongjie, Wong, Garry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545829/
https://www.ncbi.nlm.nih.gov/pubmed/37783675
http://dx.doi.org/10.1038/s41467-023-41881-8

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