Novel miRNA-based drug CD5-2 reduces liver tumor growth in diethylnitrosamine-treated mice by normalizing tumor vasculature and altering immune infiltrate

INTRODUCTION: Liver cancers exhibit abnormal (leaky) vasculature, hypoxia and an immunosuppressive microenvironment. Normalization of tumor vasculature is an emerging approach to treat many cancers. Blockmir CD5-2 is a novel oligonucleotide-based inhibitor of the miR-27a interaction with VE-Cadherin...

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Detalles Bibliográficos
Autores principales: Liu, Ken, Chen, Jinbiao, Zhao, Yang, Boland, Jade, Ting, Ka Ka, Lockwood, Glen, McKenzie, Catriona, Kench, James, Vadas, Mathew A., Gamble, Jennifer R., McCaughan, Geoffrey W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545841/
https://www.ncbi.nlm.nih.gov/pubmed/37795103
http://dx.doi.org/10.3389/fimmu.2023.1245708

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