Generation of a tyrosine hydroxylase-2A-Cre knockin non-human primate model by homology-directed-repair-biased CRISPR genome editing

Non-human primates (NHPs) are the closest animal model to humans; thus, gene engineering technology in these species holds great promise for the elucidation of higher brain functions and human disease models. Knockin (KI) gene targeting is a versatile approach to modify gene(s) of interest; however,...

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Detalles Bibliográficos
Autores principales: Yoshimatsu, Sho, Okahara, Junko, Yoshie, Junko, Igarashi, Yoko, Nakajima, Ryusuke, Sanosaka, Tsukasa, Qian, Emi, Sato, Tsukika, Kobayashi, Hiroya, Morimoto, Satoru, Kishi, Noriyuki, Pillis, Devin M., Malik, Punam, Noce, Toshiaki, Okano, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545943/
https://www.ncbi.nlm.nih.gov/pubmed/37714158
http://dx.doi.org/10.1016/j.crmeth.2023.100590

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