Inferring single-cell transcriptomic dynamics with structured latent gene expression dynamics

Gene expression dynamics provide directional information for trajectory inference from single-cell RNA sequencing data. Traditional approaches compute RNA velocity using strict modeling assumptions about transcription and splicing of RNA. This can fail in scenarios where multiple lineages have disti...

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Detalles Bibliográficos
Autores principales: Farrell, Spencer, Mani, Madhav, Goyal, Sidhartha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10545944/
https://www.ncbi.nlm.nih.gov/pubmed/37708894
http://dx.doi.org/10.1016/j.crmeth.2023.100581

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