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Traumatic brain injury-associated epigenetic changes and the risk for neurodegenerative diseases

Epidemiological studies have shown that traumatic brain injury (TBI) increases the risk for developing neurodegenerative diseases (NDs). However, molecular mechanisms that underlie this risk are largely unidentified. TBI triggers widespread epigenetic modifications. Similarly, NDs such as Alzheimer’...

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Detalles Bibliográficos
Autores principales: Smolen, Paul, Dash, Pramod K., Redell, John B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546067/
https://www.ncbi.nlm.nih.gov/pubmed/37795186
http://dx.doi.org/10.3389/fnins.2023.1259405
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author Smolen, Paul
Dash, Pramod K.
Redell, John B.
author_facet Smolen, Paul
Dash, Pramod K.
Redell, John B.
author_sort Smolen, Paul
collection PubMed
description Epidemiological studies have shown that traumatic brain injury (TBI) increases the risk for developing neurodegenerative diseases (NDs). However, molecular mechanisms that underlie this risk are largely unidentified. TBI triggers widespread epigenetic modifications. Similarly, NDs such as Alzheimer’s or Parkinson’s are associated with numerous epigenetic changes. Although epigenetic changes can persist after TBI, it is unresolved if these modifications increase the risk of later ND development and/or dementia. We briefly review TBI-related epigenetic changes, and point out putative feedback loops that might contribute to long-term persistence of some modifications. We then focus on evidence suggesting persistent TBI-associated epigenetic changes may contribute to pathological processes (e.g., neuroinflammation) which may facilitate the development of specific NDs – Alzheimer’s disease, Parkinson’s disease, or chronic traumatic encephalopathy. Finally, we discuss possible directions for TBI therapies that may help prevent or delay development of NDs.
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spelling pubmed-105460672023-10-04 Traumatic brain injury-associated epigenetic changes and the risk for neurodegenerative diseases Smolen, Paul Dash, Pramod K. Redell, John B. Front Neurosci Neuroscience Epidemiological studies have shown that traumatic brain injury (TBI) increases the risk for developing neurodegenerative diseases (NDs). However, molecular mechanisms that underlie this risk are largely unidentified. TBI triggers widespread epigenetic modifications. Similarly, NDs such as Alzheimer’s or Parkinson’s are associated with numerous epigenetic changes. Although epigenetic changes can persist after TBI, it is unresolved if these modifications increase the risk of later ND development and/or dementia. We briefly review TBI-related epigenetic changes, and point out putative feedback loops that might contribute to long-term persistence of some modifications. We then focus on evidence suggesting persistent TBI-associated epigenetic changes may contribute to pathological processes (e.g., neuroinflammation) which may facilitate the development of specific NDs – Alzheimer’s disease, Parkinson’s disease, or chronic traumatic encephalopathy. Finally, we discuss possible directions for TBI therapies that may help prevent or delay development of NDs. Frontiers Media S.A. 2023-09-19 /pmc/articles/PMC10546067/ /pubmed/37795186 http://dx.doi.org/10.3389/fnins.2023.1259405 Text en Copyright © 2023 Smolen, Dash and Redell. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Smolen, Paul
Dash, Pramod K.
Redell, John B.
Traumatic brain injury-associated epigenetic changes and the risk for neurodegenerative diseases
title Traumatic brain injury-associated epigenetic changes and the risk for neurodegenerative diseases
title_full Traumatic brain injury-associated epigenetic changes and the risk for neurodegenerative diseases
title_fullStr Traumatic brain injury-associated epigenetic changes and the risk for neurodegenerative diseases
title_full_unstemmed Traumatic brain injury-associated epigenetic changes and the risk for neurodegenerative diseases
title_short Traumatic brain injury-associated epigenetic changes and the risk for neurodegenerative diseases
title_sort traumatic brain injury-associated epigenetic changes and the risk for neurodegenerative diseases
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546067/
https://www.ncbi.nlm.nih.gov/pubmed/37795186
http://dx.doi.org/10.3389/fnins.2023.1259405
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