Optimization of universal allogeneic CAR-T cells combining CRISPR and transposon-based technologies for treatment of acute myeloid leukemia

Despite the potential of CAR-T therapies for hematological malignancies, their efficacy in patients with relapse and refractory Acute Myeloid Leukemia has been limited. The aim of our study has been to develop and manufacture a CAR-T cell product that addresses some of the current limitations. We in...

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Detalles Bibliográficos
Autores principales: Calviño, Cristina, Ceballos, Candela, Alfonso, Ana, Jauregui, Patricia, Calleja-Cervantes, Maria E., San Martin-Uriz, Patxi, Rodriguez-Marquez, Paula, Martin-Mallo, Angel, Iglesias, Elena, Abizanda, Gloria, Rodriguez-Diaz, Saray, Martinez-Turrillas, Rebeca, Illarramendi, Jorge, Viguria, Maria C., Redondo, Margarita, Rifon, Jose, Villar, Sara, Lasarte, Juan J., Inoges, Susana, Lopez-Diaz de Cerio, Ascension, Hernaez, Mikel, Prosper, Felipe, Rodriguez-Madoz, Juan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10546312/
https://www.ncbi.nlm.nih.gov/pubmed/37795087
http://dx.doi.org/10.3389/fimmu.2023.1270843

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